6-chloro-N₄-(3-chloro-2-fluorophenyl)pyrimidine-4,5-diamine

Base Information

• Chemical Name: 6-chloro-N₄-(3-chloro-2-fluorophenyl)pyrimidine-4,5-diamine
• CAS No.: 833451-52-8
• Molecular Formula: C₁₀H₇Cl₂FN₄
• Molecular Weight: 273.097
• Mol file: 833451-52-8.mol

Synonyms:6-chloro-N₄-(3-chloro-2-fluorophenyl)pyrimidine-4,5-diamine

Chemical Property of 6-chloro-N₄-(3-chloro-2-fluorophenyl)pyrimidine-4,5-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-chloro-N₄-(3-chloro-2-fluorophenyl)pyrimidine-4,5-diamine

There total 1 articles about 6-chloro-N₄-(3-chloro-2-fluorophenyl)pyrimidine-4,5-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

5-amino-4,6-dichloropyridimine (5413-85-4) + 3-chloro-2-fluoroaniline (2106-04-9) → 6-chloro-N4-(3-chloro-2-fluorophenyl)pyrimidine-4,5-diamine (833451-52-8)

Guidance literature:

With hydrogenchloride; In ethanol; water; Heating;

DOI:10.1080/00397910500377479

Reference yield: 88.0%

6-chloro-N4-(3-chloro-2-fluorophenyl)pyrimidine-4,5-diamine (833451-52-8) + 2,5-dihydroxy-4-methoxy-benzaldehyde (29865-97-2) → 1-(3-chloro-2-fluoro-phenylamino)-7-methoxy-5-oxa-2,4,11-triazadibenzo[a,d]cyclopenten-8-ol (833451-50-6)

Guidance literature:

With hydrogenchloride; magnesium sulfate; In N,N-dimethyl-formamide; at 95 ℃;

DOI:10.1080/00397910500377479

Reference yield:

6-chloro-N4-(3-chloro-2-fluorophenyl)pyrimidine-4,5-diamine (833451-52-8) + 2,4,5-trihydroxybenzaldehyde (35094-87-2) → 1-(3-chloro-2-fluoro-phenylamino)-5-oxa-2,4,11-triaza-dibenzo[a,d]cycloheptene-7,8-diol

Guidance literature:

In N,N-dimethyl-formamide; at 100 - 120 ℃;

DOI:10.1016/j.bmcl.2006.07.031

upstream raw materials:

5-amino-4,6-dichloropyridimine

3-chloro-2-fluoroaniline

Downstream raw materials:

1-(3-chloro-2-fluoro-phenylamino)-7-methoxy-5-oxa-2,4,11-triazadibenzo[a,d]cyclopenten-8-ol

(3-chloro-2-fluoro-phenyl)-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-5-oxa-2,4,11-triazadibenzo[a,d]cyclohepten-1-yl]amine