1-(3-chloro-2-fluoro-phenylamino)-7-methoxy-5-oxa-2,4,11-triazadibenzo[a,d]cyclopenten-8-ol

Base Information

• Chemical Name: 1-(3-chloro-2-fluoro-phenylamino)-7-methoxy-5-oxa-2,4,11-triazadibenzo[a,d]cyclopenten-8-ol
• CAS No.: 833451-50-6
• Molecular Formula: C₁₈H₁₂ClFN₄O₃
• Molecular Weight: 386.77
• Mol file: 833451-50-6.mol

Synonyms:1-(3-chloro-2-fluoro-phenylamino)-7-methoxy-5-oxa-2,4,11-triazadibenzo[a,d]cyclopenten-8-ol

Chemical Property of 1-(3-chloro-2-fluoro-phenylamino)-7-methoxy-5-oxa-2,4,11-triazadibenzo[a,d]cyclopenten-8-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-chloro-2-fluoro-phenylamino)-7-methoxy-5-oxa-2,4,11-triazadibenzo[a,d]cyclopenten-8-ol

There total 3 articles about 1-(3-chloro-2-fluoro-phenylamino)-7-methoxy-5-oxa-2,4,11-triazadibenzo[a,d]cyclopenten-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

6-chloro-N4-(3-chloro-2-fluorophenyl)pyrimidine-4,5-diamine (833451-52-8) + 2,5-dihydroxy-4-methoxy-benzaldehyde (29865-97-2) → 1-(3-chloro-2-fluoro-phenylamino)-7-methoxy-5-oxa-2,4,11-triazadibenzo[a,d]cyclopenten-8-ol (833451-50-6)

Guidance literature:

With hydrogenchloride; magnesium sulfate; In N,N-dimethyl-formamide; at 95 ℃;

DOI:10.1080/00397910500377479

Reference yield:

2,4,5-trihydroxybenzaldehyde (35094-87-2) → 1-(3-chloro-2-fluoro-phenylamino)-7-methoxy-5-oxa-2,4,11-triazadibenzo[a,d]cyclopenten-8-ol (833451-50-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / cesium carbonate / dimethylformamide / 18 - 25 °C

2: 88 percent / magnesium sulfate; hydrochloric acid / dimethylformamide / 95 °C

With hydrogenchloride; magnesium sulfate; caesium carbonate; In N,N-dimethyl-formamide;

DOI:10.1080/00397910500377479

Reference yield:

3-chloro-2-fluoroaniline (2106-04-9) → 1-(3-chloro-2-fluoro-phenylamino)-7-methoxy-5-oxa-2,4,11-triazadibenzo[a,d]cyclopenten-8-ol (833451-50-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / hydrochloric acid / ethanol; H₂O / Heating

2: 88 percent / magnesium sulfate; hydrochloric acid / dimethylformamide / 95 °C

With hydrogenchloride; magnesium sulfate; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1080/00397910500377479

upstream raw materials:

6-chloro-N₄-(3-chloro-2-fluorophenyl)pyrimidine-4,5-diamine

2,5-dihydroxy-4-methoxy-benzaldehyde

2,4,5-trihydroxybenzaldehyde

3-chloro-2-fluoroaniline

Downstream raw materials:

(3-chloro-2-fluoro-phenyl)-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-5-oxa-2,4,11-triazadibenzo[a,d]cyclohepten-1-yl]amine