2-(tert-butoxy)-1-(2-nitrophenyl)-2-oxoethyl 4-((2-(tert-butoxy)-1-(2-nitrophenyl)-2-oxoethyl)amino)butanoate

Base Information

• Chemical Name: 2-(tert-butoxy)-1-(2-nitrophenyl)-2-oxoethyl 4-((2-(tert-butoxy)-1-(2-nitrophenyl)-2-oxoethyl)amino)butanoate
• CAS No.: 1541867-37-1
• Molecular Formula: C₂₈H₃₅N₃O₁₀
• Molecular Weight: 573.6
• Mol file: 1541867-37-1.mol

Synonyms:2-(tert-butoxy)-1-(2-nitrophenyl)-2-oxoethyl 4-((2-(tert-butoxy)-1-(2-nitrophenyl)-2-oxoethyl)amino)butanoate

Chemical Property of 2-(tert-butoxy)-1-(2-nitrophenyl)-2-oxoethyl 4-((2-(tert-butoxy)-1-(2-nitrophenyl)-2-oxoethyl)amino)butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(tert-butoxy)-1-(2-nitrophenyl)-2-oxoethyl 4-((2-(tert-butoxy)-1-(2-nitrophenyl)-2-oxoethyl)amino)butanoate

There total 3 articles about 2-(tert-butoxy)-1-(2-nitrophenyl)-2-oxoethyl 4-((2-(tert-butoxy)-1-(2-nitrophenyl)-2-oxoethyl)amino)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

tert-butyl 2-bromo-2-(2-nitrophenyl)acetate (158078-62-7) + 4-amino-n-butyric acid (56-12-2) → 2-(tert-butoxy)-1-(2-nitrophenyl)-2-oxoethyl 4-((2-(tert-butoxy)-1-(2-nitrophenyl)-2-oxoethyl)amino)butanoate (1541867-37-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 36h; Inert atmosphere;

DOI:10.1021/ja411082f

Reference yield:

2-(2-Nitrophenyl)essigsaeure-tert-butylester (98911-33-2) → 2-(tert-butoxy)-1-(2-nitrophenyl)-2-oxoethyl 4-((2-(tert-butoxy)-1-(2-nitrophenyl)-2-oxoethyl)amino)butanoate (1541867-37-1)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 36 h / 65 °C / Inert atmosphere

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; In tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja411082f

Reference yield:

2-(2-nitrophenyl)acetic acid (3740-52-1) → 2-(tert-butoxy)-1-(2-nitrophenyl)-2-oxoethyl 4-((2-(tert-butoxy)-1-(2-nitrophenyl)-2-oxoethyl)amino)butanoate (1541867-37-1)

Guidance literature:

Multi-step reaction with 3 steps

1: di-tert-butyl dicarbonate; dmap / 1 h / 20 °C / Inert atmosphere

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 36 h / 65 °C / Inert atmosphere

With dmap; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); di-tert-butyl dicarbonate; potassium carbonate; In tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja411082f

upstream raw materials:

2-(2-Nitrophenyl)essigsaeure-tert-butylester

tert-butyl 2-bromo-2-(2-nitrophenyl)acetate

4-amino-n-butyric acid

2-(2-nitrophenyl)acetic acid

Downstream raw materials:

2-((4-(carboxy(2-nitrophenyl)methoxy)-4-oxobutyl)amino)-2-(2-nitrophenyl)acetic acid