2-((4-(carboxy(2-nitrophenyl)methoxy)-4-oxobutyl)amino)-2-(2-nitrophenyl)acetic acid

Base Information

• Chemical Name: 2-((4-(carboxy(2-nitrophenyl)methoxy)-4-oxobutyl)amino)-2-(2-nitrophenyl)acetic acid
• CAS No.: 1541867-39-3
• Molecular Formula: C₂₀H₁₉N₃O₁₀
• Molecular Weight: 461.385
• Mol file: 1541867-39-3.mol

Synonyms:2-((4-(carboxy(2-nitrophenyl)methoxy)-4-oxobutyl)amino)-2-(2-nitrophenyl)acetic acid

Chemical Property of 2-((4-(carboxy(2-nitrophenyl)methoxy)-4-oxobutyl)amino)-2-(2-nitrophenyl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((4-(carboxy(2-nitrophenyl)methoxy)-4-oxobutyl)amino)-2-(2-nitrophenyl)acetic acid

There total 3 articles about 2-((4-(carboxy(2-nitrophenyl)methoxy)-4-oxobutyl)amino)-2-(2-nitrophenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(tert-butoxy)-1-(2-nitrophenyl)-2-oxoethyl 4-((2-(tert-butoxy)-1-(2-nitrophenyl)-2-oxoethyl)amino)butanoate (1541867-37-1) → 2-((4-(carboxy(2-nitrophenyl)methoxy)-4-oxobutyl)amino)-2-(2-nitrophenyl)acetic acid (1541867-39-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 27h; Inert atmosphere;

DOI:10.1021/ja411082f

Reference yield:

2-(2-Nitrophenyl)essigsaeure-tert-butylester (98911-33-2) → 2-((4-(carboxy(2-nitrophenyl)methoxy)-4-oxobutyl)amino)-2-(2-nitrophenyl)acetic acid (1541867-39-3)

Guidance literature:

Multi-step reaction with 3 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 36 h / 65 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 27 h / Inert atmosphere

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; trifluoroacetic acid; In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja411082f

Reference yield:

2-(2-nitrophenyl)acetic acid (3740-52-1) → 2-((4-(carboxy(2-nitrophenyl)methoxy)-4-oxobutyl)amino)-2-(2-nitrophenyl)acetic acid (1541867-39-3)

Guidance literature:

Multi-step reaction with 4 steps

1: di-tert-butyl dicarbonate; dmap / 1 h / 20 °C / Inert atmosphere

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 36 h / 65 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 27 h / Inert atmosphere

With dmap; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); di-tert-butyl dicarbonate; potassium carbonate; trifluoroacetic acid; In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja411082f

upstream raw materials:

2-(2-Nitrophenyl)essigsaeure-tert-butylester

2-(tert-butoxy)-1-(2-nitrophenyl)-2-oxoethyl 4-((2-(tert-butoxy)-1-(2-nitrophenyl)-2-oxoethyl)amino)butanoate

2-(2-nitrophenyl)acetic acid