(E)-3-[8-[2-(3-methoxyphenyl)vinyl]-2,6-dioxo-1-prop-2-ynyl-1,2,6,7-tetrahydropurin-3-yl]propyl acetate

Base Information

Chemical Name:(E)-3-[8-[2-(3-methoxyphenyl)vinyl]-2,6-dioxo-1-prop-2-ynyl-1,2,6,7-tetrahydropurin-3-yl]propyl acetate
CAS No.:702697-13-0
Molecular Formula:C₂₂H₂₂N₄O₅
Molecular Weight:422.44
Hs Code.:

Synonyms:(E)-3-[8-[2-(3-methoxyphenyl)vinyl]-2,6-dioxo-1-prop-2-ynyl-1,2,6,7-tetrahydropurin-3-yl]propyl acetate

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Chemical Property of (E)-3-[8-[2-(3-methoxyphenyl)vinyl]-2,6-dioxo-1-prop-2-ynyl-1,2,6,7-tetrahydropurin-3-yl]propyl acetate

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Technology Process of (E)-3-[8-[2-(3-methoxyphenyl)vinyl]-2,6-dioxo-1-prop-2-ynyl-1,2,6,7-tetrahydropurin-3-yl]propyl acetate

There total 5 articles about (E)-3-[8-[2-(3-methoxyphenyl)vinyl]-2,6-dioxo-1-prop-2-ynyl-1,2,6,7-tetrahydropurin-3-yl]propyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 702697-10-7
3-{6-amino-5-[3-(3-methoxyphenyl)acryloylamino]-2,4-dioxo-3-prop-2-ynyl-3,4-dihydro-2H-pyrimidin-1-yl}propyl acetate

: 702697-13-0
(E)-3-[8-[2-(3-methoxyphenyl)vinyl]-2,6-dioxo-1-prop-2-ynyl-1,2,6,7-tetrahydropurin-3-yl]propyl acetate

Guidance literature:: With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane; for 16h; Heating;
DOI:10.1021/jo0358574

Reference yield:

: 138895-22-4
6-amino-3-prop-2-ynyl-1H,3H-pyrimidine-2,4-dione

: 702697-13-0
(E)-3-[8-[2-(3-methoxyphenyl)vinyl]-2,6-dioxo-1-prop-2-ynyl-1,2,6,7-tetrahydropurin-3-yl]propyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / acetic acid; NaNO₂ / H₂O / 65 °C

2: 67 percent / NH₃; sodium dithionite / H₂O / 0.17 h / 70 °C

3: 80 percent / pyridine / ethyl acetate / 16 h / 20 °C

4: 92 percent / K₂CO₃ / dimethylformamide / 24 h / 20 °C

5: 85 percent / 1,1,1,3,3,3-hyxamethyldisilazane; (NH₄)2SO₄ / 16 h / Heating

With pyridine; ammonium sulfate; sodium dithionite; ammonia; potassium carbonate; acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane; sodium nitrite; In water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo0358574

Reference yield:

: 146830-70-8
6-amino-5-nitroso-3-prop-2-ynyl-1H,3H-pyrimidine-2,4-dione

: 702697-13-0
(E)-3-[8-[2-(3-methoxyphenyl)vinyl]-2,6-dioxo-1-prop-2-ynyl-1,2,6,7-tetrahydropurin-3-yl]propyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / NH₃; sodium dithionite / H₂O / 0.17 h / 70 °C

2: 80 percent / pyridine / ethyl acetate / 16 h / 20 °C

3: 92 percent / K₂CO₃ / dimethylformamide / 24 h / 20 °C

4: 85 percent / 1,1,1,3,3,3-hyxamethyldisilazane; (NH₄)2SO₄ / 16 h / Heating

With pyridine; ammonium sulfate; sodium dithionite; ammonia; potassium carbonate; 1,1,1,3,3,3-hexamethyl-disilazane; In water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo0358574