(E)-3-[8-[2-(3-methoxyphenyl)vinyl]-7-methyl-2,6-dioxo-1-prop-2-ynyl-1,2,6,7-tetrahydropurin-3-yl]propyl acetate

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Chemical Name:(E)-3-[8-[2-(3-methoxyphenyl)vinyl]-7-methyl-2,6-dioxo-1-prop-2-ynyl-1,2,6,7-tetrahydropurin-3-yl]propyl acetate
CAS No.:702697-16-3
Molecular Formula:C₂₃H₂₄N₄O₅
Molecular Weight:436.467
Hs Code.:

Synonyms:(E)-3-[8-[2-(3-methoxyphenyl)vinyl]-7-methyl-2,6-dioxo-1-prop-2-ynyl-1,2,6,7-tetrahydropurin-3-yl]propyl acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-3-[8-[2-(3-methoxyphenyl)vinyl]-7-methyl-2,6-dioxo-1-prop-2-ynyl-1,2,6,7-tetrahydropurin-3-yl]propyl acetate

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Technology Process of (E)-3-[8-[2-(3-methoxyphenyl)vinyl]-7-methyl-2,6-dioxo-1-prop-2-ynyl-1,2,6,7-tetrahydropurin-3-yl]propyl acetate

There total 6 articles about (E)-3-[8-[2-(3-methoxyphenyl)vinyl]-7-methyl-2,6-dioxo-1-prop-2-ynyl-1,2,6,7-tetrahydropurin-3-yl]propyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 74-88-4
methyl iodide

: 702697-13-0
(E)-3-[8-[2-(3-methoxyphenyl)vinyl]-2,6-dioxo-1-prop-2-ynyl-1,2,6,7-tetrahydropurin-3-yl]propyl acetate

: 702697-16-3
(E)-3-[8-[2-(3-methoxyphenyl)vinyl]-7-methyl-2,6-dioxo-1-prop-2-ynyl-1,2,6,7-tetrahydropurin-3-yl]propyl acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 5h;
DOI:10.1021/jo0358574

Reference yield:

: 138895-22-4
6-amino-3-prop-2-ynyl-1H,3H-pyrimidine-2,4-dione

: 702697-16-3
(E)-3-[8-[2-(3-methoxyphenyl)vinyl]-7-methyl-2,6-dioxo-1-prop-2-ynyl-1,2,6,7-tetrahydropurin-3-yl]propyl acetate

Guidance literature:: Multi-step reaction with 6 steps

1: 72 percent / acetic acid; NaNO₂ / H₂O / 65 °C

2: 67 percent / NH₃; sodium dithionite / H₂O / 0.17 h / 70 °C

3: 80 percent / pyridine / ethyl acetate / 16 h / 20 °C

4: 92 percent / K₂CO₃ / dimethylformamide / 24 h / 20 °C

5: 85 percent / 1,1,1,3,3,3-hyxamethyldisilazane; (NH₄)2SO₄ / 16 h / Heating

6: 98 percent / K₂CO₃ / dimethylformamide / 5 h / 20 °C

With pyridine; ammonium sulfate; sodium dithionite; ammonia; potassium carbonate; acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane; sodium nitrite; In water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo0358574

Reference yield:

: 146830-70-8
6-amino-5-nitroso-3-prop-2-ynyl-1H,3H-pyrimidine-2,4-dione

: 702697-16-3
(E)-3-[8-[2-(3-methoxyphenyl)vinyl]-7-methyl-2,6-dioxo-1-prop-2-ynyl-1,2,6,7-tetrahydropurin-3-yl]propyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / NH₃; sodium dithionite / H₂O / 0.17 h / 70 °C

2: 80 percent / pyridine / ethyl acetate / 16 h / 20 °C

3: 92 percent / K₂CO₃ / dimethylformamide / 24 h / 20 °C

4: 85 percent / 1,1,1,3,3,3-hyxamethyldisilazane; (NH₄)2SO₄ / 16 h / Heating

5: 98 percent / K₂CO₃ / dimethylformamide / 5 h / 20 °C

With pyridine; ammonium sulfate; sodium dithionite; ammonia; potassium carbonate; 1,1,1,3,3,3-hexamethyl-disilazane; In water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo0358574