(S)-4-(8-amino-3-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-7-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Base Information

Chemical Name:(S)-4-(8-amino-3-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-7-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide
CAS No.:1620564-27-3
Molecular Formula:C₂₆H₁₉F₆N₉O
Molecular Weight:587.487
Hs Code.:

(S)-4-(8-amino-3-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-7-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Synonyms:(S)-4-(8-amino-3-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-7-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

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Chemical Property of (S)-4-(8-amino-3-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-7-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

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Technology Process of (S)-4-(8-amino-3-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-7-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

There total 14 articles about (S)-4-(8-amino-3-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-7-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620564-29-5
4-(8-amino-3-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-7-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

: 1620564-27-3
(S)-4-(8-amino-3-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-7-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

: 1620564-28-4
(R)-4-(8-amino-3-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-7-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Guidance literature:: With chiralpak AD-H 250x4.6mm I_.D_., 5um; Resolution of racemate;

Reference yield:

: 1620564-61-5
ethyl 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine-7-carboxylate

: 1620564-27-3
(S)-4-(8-amino-3-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-7-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

: 1620564-28-4
(R)-4-(8-amino-3-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-7-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 8 steps

1: lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 20 °C

2: phosgene / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 0 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 60 °C

4: N,N-dimethyl-formamide; trichlorophosphate / acetonitrile / 0.08 h / 0 - 70 °C

5: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.17 h / Cooling with ice

6: ammonia / isopropyl alcohol / 24 h / 100 °C / Sealed tube

7: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / water; 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

8: chiralpak AD-H 250x4.6mm I_.D_., 5um / Resolution of racemate

With phosgene; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; lithium hydroxide monohydrate; ammonia; potassium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 1620564-62-6
3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine-7-carboxylic acid

: 1620564-27-3
(S)-4-(8-amino-3-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-7-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

: 1620564-28-4
(R)-4-(8-amino-3-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-7-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: phosgene / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 0 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 60 °C

3: N,N-dimethyl-formamide; trichlorophosphate / acetonitrile / 0.08 h / 0 - 70 °C

4: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.17 h / Cooling with ice

5: ammonia / isopropyl alcohol / 24 h / 100 °C / Sealed tube

6: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / water; 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

7: chiralpak AD-H 250x4.6mm I_.D_., 5um / Resolution of racemate

With phosgene; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ammonia; potassium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;