benzyl 1-(1-ethoxy-2-oxo-4-phenylbutan-3-ylamino)-4-methyl-1-oxopentan-2-ylcarbamate

Base Information

Chemical Name:benzyl 1-(1-ethoxy-2-oxo-4-phenylbutan-3-ylamino)-4-methyl-1-oxopentan-2-ylcarbamate
CAS No.:1256776-25-6
Molecular Formula:C₂₆H₃₄N₂O₅
Molecular Weight:454.566
Hs Code.:

Synonyms:benzyl 1-(1-ethoxy-2-oxo-4-phenylbutan-3-ylamino)-4-methyl-1-oxopentan-2-ylcarbamate

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Chemical Property of benzyl 1-(1-ethoxy-2-oxo-4-phenylbutan-3-ylamino)-4-methyl-1-oxopentan-2-ylcarbamate

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Technology Process of benzyl 1-(1-ethoxy-2-oxo-4-phenylbutan-3-ylamino)-4-methyl-1-oxopentan-2-ylcarbamate

There total 3 articles about benzyl 1-(1-ethoxy-2-oxo-4-phenylbutan-3-ylamino)-4-methyl-1-oxopentan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1256776-44-9
benzyl 1-(1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-ylamino)-4-methyl-1-oxopent-2-ylcarbamate

: 3188-13-4
ethyl chloromethyl ether

: 1256776-25-6
benzyl 1-(1-ethoxy-2-oxo-4-phenylbutan-3-ylamino)-4-methyl-1-oxopentan-2-ylcarbamate

Guidance literature:: ethyl chloromethyl ether; With magnesium; mercury dichloride; In tetrahydrofuran; Reflux; Inert atmosphere;

benzyl 1-(1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-ylamino)-4-methyl-1-oxopent-2-ylcarbamate; In tetrahydrofuran; at -78 - -25 ℃; for 0.75h; Inert atmosphere;
DOI:10.1021/jm1009567

Reference yield:

: 10473-38-8,16679-86-0,120342-23-6,4818-00-2
N-(benzyloxycarbonyl)-L-leucyl-L-phenylalanine methyl ester

: 1256776-25-6
benzyl 1-(1-ethoxy-2-oxo-4-phenylbutan-3-ylamino)-4-methyl-1-oxopentan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; sodium hydroxide / methanol / 20 °C

2.1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: magnesium; mercury dichloride / tetrahydrofuran / Reflux; Inert atmosphere

3.2: 0.75 h / -78 - -25 °C / Inert atmosphere

With dmap; water; benzotriazol-1-ol; magnesium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; mercury dichloride; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 3.2: Grignard reaction;
DOI:10.1021/jm1009567

Reference yield:

: 6401-63-4
N-benzyloxycarbonyl-L-leucyl-L-phenylalanine

: 1256776-25-6
benzyl 1-(1-ethoxy-2-oxo-4-phenylbutan-3-ylamino)-4-methyl-1-oxopentan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: magnesium; mercury dichloride / tetrahydrofuran / Reflux; Inert atmosphere

2.2: 0.75 h / -78 - -25 °C / Inert atmosphere

With dmap; benzotriazol-1-ol; magnesium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; mercury dichloride; In tetrahydrofuran; dichloromethane; 2.2: Grignard reaction;
DOI:10.1021/jm1009567