(S)-2-(2,6-Dichloro-benzoylamino)-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid

Base Information

• Chemical Name: (S)-2-(2,6-Dichloro-benzoylamino)-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid
• CAS No.: 863226-76-0
• Molecular Formula: C₂₂H₁₉Cl₂N₃O₅
• Molecular Weight: 476.316
• Mol file: 863226-76-0.mol

Synonyms:(S)-2-(2,6-Dichloro-benzoylamino)-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid

Chemical Property of (S)-2-(2,6-Dichloro-benzoylamino)-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(2,6-Dichloro-benzoylamino)-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid

There total 5 articles about (S)-2-(2,6-Dichloro-benzoylamino)-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

(S)-2-(2,6-dichloro-benzoylamino)-3-(4-boronophenyl)-propionic acid (863228-94-8) + 4-chloro-5-methoxy-2-methyl-2H-pyridazin-3-one (14628-57-0) → (S)-2-(2,6-Dichloro-benzoylamino)-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid (863226-76-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In acetonitrile; at 150 ℃; for 0.166667h; microwave irradiation;

DOI:10.1021/jm060031q

Reference yield:

(S)-2-(2,6-Dichloro-benzoylamino)-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid methyl ester (863228-06-2) → (S)-2-(2,6-Dichloro-benzoylamino)-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid (863226-76-0)

Guidance literature:

(S)-2-(2,6-Dichloro-benzoylamino)-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid methyl ester; With methanol; lithium hydroxide; water; at 20 ℃; for 4h;

With hydrogenchloride; water;

Reference yield:

p-borono-L-phenylalanine (76410-58-7) → (S)-2-(2,6-Dichloro-benzoylamino)-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid (863226-76-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / Na₂CO₃ / acetonitrile; H₂O / 1 h / 50 °C

2: 58 percent / aq. sodium carbonate; Pd(PPh₃)2Cl₂ / acetonitrile / 0.17 h / 150 °C / microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In water; acetonitrile; 2: Suzuki coupling;

DOI:10.1021/jm060031q

upstream raw materials:

(S)-2-(2,6-dichloro-benzoylamino)-3-(4-boronophenyl)-propionic acid

4-chloro-5-methoxy-2-methyl-2H-pyridazin-3-one

p-borono-L-phenylalanine

2,6-Dichlorobenzoyl chloride

Downstream raw materials:

C₂₆H₂₃Cl₂N₅O₄