863228-06-2Relevant academic research and scientific papers
Synthesis and biological evaluation of novel pyridazinone-based α4 integrin receptor antagonists
Gong, Yong,Barbay, J. Kent,Dyatkin, Alexey B.,Miskowski, Tamara A.,Kimball, Edward S.,Prouty, Stephen M.,Fisher, M. Carolyn,Santulli, Rosemary J.,Schneider, Craig R.,Wallace, Nathaniel H.,Ballentine, Scott A.,Hageman, William E.,Masucci, John A.,Maryanoff, Bruce E.,Damiano, Bruce P.,Andrade-Gordon, Patricia,Hlasta, Dennis J.,Hornby, Pamela J.,He, Wei
, p. 3402 - 3411 (2007/10/03)
A novel series of pyridazinone-functionalized phenylalanine analogues was prepared and evaluated for inhibition of cellular adhesion mediated by α4β1/VCAM-1 and α4β 7MAdCAM-1 interactions. Concise syntheses were
Pyridazinones as antagonists of alpha4 integrins
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Page/Page column 28, (2010/02/13)
The present invention relates to certain novel compounds of Formula (I): methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of integrin mediated disorders.
