4-(3-chlorophenyl)-5-cyano-2-methyl-6-thioxo-1,4,5,6-tetrahydropyridine-3-carboxylate acid methyl ester

Base Information

• Chemical Name: 4-(3-chlorophenyl)-5-cyano-2-methyl-6-thioxo-1,4,5,6-tetrahydropyridine-3-carboxylate acid methyl ester
• CAS No.: 909547-42-8
• Molecular Formula: C₁₅H₁₃ClN₂O₂S
• Molecular Weight: 320.799
• Mol file: 909547-42-8.mol

Synonyms:4-(3-chlorophenyl)-5-cyano-2-methyl-6-thioxo-1,4,5,6-tetrahydropyridine-3-carboxylate acid methyl ester

Chemical Property of 4-(3-chlorophenyl)-5-cyano-2-methyl-6-thioxo-1,4,5,6-tetrahydropyridine-3-carboxylate acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-chlorophenyl)-5-cyano-2-methyl-6-thioxo-1,4,5,6-tetrahydropyridine-3-carboxylate acid methyl ester

There total 1 articles about 4-(3-chlorophenyl)-5-cyano-2-methyl-6-thioxo-1,4,5,6-tetrahydropyridine-3-carboxylate acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

piperidinium 4-(3-chlorophenyl)-5-cyano-3-methoxycarbonyl-2-methyl-1,4-dihydropyridine-6-thiolate → 4-(3-chlorophenyl)-5-cyano-2-methyl-6-thioxo-1,4,5,6-tetrahydropyridine-3-carboxylate acid methyl ester (909547-42-8)

Guidance literature:

With hydrogenchloride; In ethanol; at 20 ℃; for 0.5h;

DOI:10.1515/HC.2006.12.3-4.281

Reference yield: 89.0%

4-(3-chlorophenyl)-5-cyano-2-methyl-6-thioxo-1,4,5,6-tetrahydropyridine-3-carboxylate acid methyl ester (909547-42-8) + iodacetamide (144-48-9) → 6-carbamoylmethylthio-4-(3-chlorophenyl)-5-cyano-2-methyl-1,4-dihydropyridine-3-carboxylic acid methyl ester

Guidance literature:

4-(3-chlorophenyl)-5-cyano-2-methyl-6-thioxo-1,4,5,6-tetrahydropyridine-3-carboxylate acid methyl ester; With ammonium hydroxide; In ethanol; water; at 20 ℃;

iodacetamide; In ethanol; water; at 20 ℃;

DOI:10.1515/HC.2006.12.3-4.281

Reference yield: 88.0%

4-(3-chlorophenyl)-5-cyano-2-methyl-6-thioxo-1,4,5,6-tetrahydropyridine-3-carboxylate acid methyl ester (909547-42-8) + Chloroacetamide (79-07-2) → 6-carbamoylmethylthio-4-(3-chlorophenyl)-5-cyano-2-methyl-1,4-dihydropyridine-3-carboxylic acid methyl ester

Guidance literature:

4-(3-chlorophenyl)-5-cyano-2-methyl-6-thioxo-1,4,5,6-tetrahydropyridine-3-carboxylate acid methyl ester; With ammonium hydroxide; In ethanol; water; at 20 ℃;

Chloroacetamide; In ethanol; water; at 20 ℃;

DOI:10.1515/HC.2006.12.3-4.281