3a,4,5,6-tetrahydro-3a,6,6-trimethyl-3-[4-(4-methylphenyl)but-1-en-3-ynyl]-2-phenylpyrrolo[1,2-b]isoxazole

Base Information

Chemical Name:3a,4,5,6-tetrahydro-3a,6,6-trimethyl-3-[4-(4-methylphenyl)but-1-en-3-ynyl]-2-phenylpyrrolo[1,2-b]isoxazole
CAS No.:428517-12-8
Molecular Formula:C₂₆H₂₇NO
Molecular Weight:369.506
Hs Code.:

Synonyms:3a,4,5,6-tetrahydro-3a,6,6-trimethyl-3-[4-(4-methylphenyl)but-1-en-3-ynyl]-2-phenylpyrrolo[1,2-b]isoxazole

Suppliers and Price of 3a,4,5,6-tetrahydro-3a,6,6-trimethyl-3-[4-(4-methylphenyl)but-1-en-3-ynyl]-2-phenylpyrrolo[1,2-b]isoxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3a,4,5,6-tetrahydro-3a,6,6-trimethyl-3-[4-(4-methylphenyl)but-1-en-3-ynyl]-2-phenylpyrrolo[1,2-b]isoxazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3a,4,5,6-tetrahydro-3a,6,6-trimethyl-3-[4-(4-methylphenyl)but-1-en-3-ynyl]-2-phenylpyrrolo[1,2-b]isoxazole

There total 3 articles about 3a,4,5,6-tetrahydro-3a,6,6-trimethyl-3-[4-(4-methylphenyl)but-1-en-3-ynyl]-2-phenylpyrrolo[1,2-b]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 624-31-7
4-tolyl iodide

: 428516-88-5
(Z)-3-(but-1-en-3-enyl)-3a,4,5,6-tetrahydro-3a,6,6-trimethyl-2-phenylpyrrolo[1,2-b]isoxazole

: 428517-12-8
3a,4,5,6-tetrahydro-3a,6,6-trimethyl-3-[4-(4-methylphenyl)but-1-en-3-ynyl]-2-phenylpyrrolo[1,2-b]isoxazole

Guidance literature:: With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; for 3h;
DOI:10.1002/1522-2675(20011219)84:12<3822::AID-HLCA3822>3.0.CO;2-O

Reference yield:

: 355019-18-0
3a,6,6-trimethyl-2-phenyl-3a,4,5,6-tetrahydropyrrolo[1,2-b]isoxazol-3-carbaldehyde

: 428517-12-8
3a,4,5,6-tetrahydro-3a,6,6-trimethyl-3-[4-(4-methylphenyl)but-1-en-3-ynyl]-2-phenylpyrrolo[1,2-b]isoxazole

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / BuLi; (i-PrO)4Ti / tetrahydrofuran; hexane / 1.75 h / -78 - 20 °C

2: 99 percent / K₂CO₃ / methanol / 24 h / 20 °C

3: 98 percent / CuI; Et₃N / PdCl₂(PPh₃)2 / 3 h

With titanium(IV) isopropylate; copper(l) iodide; n-butyllithium; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; hexane; 1: Peterson olefination / 3: Sonogashira coupling;
DOI:10.1002/1522-2675(20011219)84:12<3822::AID-HLCA3822>3.0.CO;2-O

Reference yield:

: 428516-73-8
(Z)-3a,4,5,6-tetrahydro-3a,6,6-trimethyl-2-phenyl-3-[4-(trimethylsilyl)but-1-en-3-ynyl]pyrrolo[1,2-b]isoxazole

: 428517-12-8
3a,4,5,6-tetrahydro-3a,6,6-trimethyl-3-[4-(4-methylphenyl)but-1-en-3-ynyl]-2-phenylpyrrolo[1,2-b]isoxazole

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / K₂CO₃ / methanol / 24 h / 20 °C

2: 98 percent / CuI; Et₃N / PdCl₂(PPh₃)2 / 3 h

With copper(l) iodide; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In methanol; 2: Sonogashira coupling;
DOI:10.1002/1522-2675(20011219)84:12<3822::AID-HLCA3822>3.0.CO;2-O