(E)-3-PHENYL-1-(PYRROLIDIN-1-YL)PROP-2-EN-1-ONE

Base Information

• Chemical Name: (E)-3-PHENYL-1-(PYRROLIDIN-1-YL)PROP-2-EN-1-ONE
• CAS No.: 19202-21-2
• Molecular Formula: C13H15 N O
• Molecular Weight: 201.268
• Mol file: 19202-21-2.mol

Synonyms:Pyrrolidine,1-(1-oxo-3-phenyl-2-propenyl)- (9CI); Pyrrolidine, 1-cinnamoyl- (8CI);1-Cinnamoylpyrrolidine; 3-Phenyl-1-(1-pyrrolidinyl)-2-propen-1-one

Chemical Property of (E)-3-PHENYL-1-(PYRROLIDIN-1-YL)PROP-2-EN-1-ONE

Chemical Property:

• PSA: 20.31000
• LogP: 2.26010

Purity/Quality:

99% ^*data from raw suppliers

(E)-3-PHENYL-1-(PYRROLIDIN-1-YL)PROP-2-EN-1-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (E)-3-PHENYL-1-(PYRROLIDIN-1-YL)PROP-2-EN-1-ONE

There total 39 articles about (E)-3-PHENYL-1-(PYRROLIDIN-1-YL)PROP-2-EN-1-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

pyrrolidine (123-75-1) + (E)-3-phenylacrylic acid (140-10-3) → 1-trans-cinnamoylpyrrolidine (19202-21-2,52438-21-8)

Guidance literature:

With 1-(tert-butoxy)-2-(tert-butoxy)carbonyl-1,2-dihydroisoquinoline; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1016/j.tet.2008.09.094

Reference yield: 96.0%

pyrrolidine (123-75-1) + Cinnamoyl chloride (102-92-1,17082-09-6) → 1-trans-cinnamoylpyrrolidine (19202-21-2,52438-21-8)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 ℃; for 12h;

DOI:10.1002/hlca.200290012

Reference yield: 95.0%

(N-pyrrolidinylcarbonylmethyl)triphenylarsonium bromide (112601-96-4) + benzaldehyde (100-52-7) → 1-trans-cinnamoylpyrrolidine (19202-21-2,52438-21-8)

Guidance literature:

With potassium carbonate; In acetonitrile; at 25 ℃; for 10h;

DOI:10.1016/S0040-4039(00)96069-6

upstream raw materials:

N-trimethylsilylpyrrolidine

trans-cinnamoyl fluoride

E-styryl iodide

trimethylpyrrolidinylcarbonylstannane

Downstream raw materials:

((2S,3R)-3-Phenyl-oxiranyl)-pyrrolidin-1-yl-methanone

(E)-3-phenyl-1-pyrrolidin-1-yl propenethione

1-{[(2S,3R)-3-phenylaziridin-2-yl]carbonyl}pyrrolidine

[(1S,2S,3R)-2-Phenyl-3-((E)-2-trimethylsilanyl-vinyl)-cyclopropyl]-pyrrolidin-1-yl-methanone