Technology Process of N-isopropyl-3-{3-[5-(2-methoxyethoxy)pyrimidin-2-yl]benzyl}-1,2,4-triazolo[4,3-b]pyridazine-6-carboxamide
There total 9 articles about N-isopropyl-3-{3-[5-(2-methoxyethoxy)pyrimidin-2-yl]benzyl}-1,2,4-triazolo[4,3-b]pyridazine-6-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: thionyl chloride / 2 h / 10 - 20 °C
2.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 96 h / 80 °C
3.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; ethanol / 20 h / 80 °C
3.2: 24 h / 80 °C
3.3: pH 6
4.1: hydrazine hydrate / methanol / 20 h / 70 °C
5.1: potassium iodide / 130 °C
6.1: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide
7.1: water; sodium perborate / tetrahydrofuran
8.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran
9.1: water; lithium hydroxide / methanol
10.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide
With
4-methyl-morpholine; sodium perborate; thionyl chloride; di-isopropyl azodicarboxylate; water; potassium acetate; potassium carbonate; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; potassium iodide; lithium hydroxide;
bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 96 h / 80 °C
2.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; ethanol / 20 h / 80 °C
2.2: 24 h / 80 °C
2.3: pH 6
3.1: hydrazine hydrate / methanol / 20 h / 70 °C
4.1: potassium iodide / 130 °C
5.1: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide
6.1: water; sodium perborate / tetrahydrofuran
7.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran
8.1: water; lithium hydroxide / methanol
9.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide
With
4-methyl-morpholine; sodium perborate; di-isopropyl azodicarboxylate; water; potassium acetate; potassium carbonate; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; potassium iodide; lithium hydroxide;
bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; toluene;
