N¹-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N⁴-(phenylmethyl)succinamide

Base Information

• Chemical Name: N¹-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N⁴-(phenylmethyl)succinamide
• CAS No.: 1621317-95-0
• Molecular Formula: C₃₄H₃₆N₆O₅S
• Molecular Weight: 640.763

Synonyms:N¹-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N⁴-(phenylmethyl)succinamide

Chemical Property of N¹-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N⁴-(phenylmethyl)succinamide

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Technology Process of N¹-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N⁴-(phenylmethyl)succinamide

There total 8 articles about N¹-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N⁴-(phenylmethyl)succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

4-oxo-4-[(phenylmethyl)amino]butanoic acid (64984-60-7) + 8-amino-3-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl][1]benzothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (1621317-76-7) + chloroformic acid ethyl ester (541-41-3) → N1-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N4-(phenylmethyl)succinamide (1621317-95-0)

Guidance literature:

4-oxo-4-[(phenylmethyl)amino]butanoic acid; With triethylamine; In tetrahydrofuran; for 0.0833333h; Cooling with ice;

chloroformic acid ethyl ester; In tetrahydrofuran; for 0.25h;

8-amino-3-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl][1]benzothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1016/j.ejmech.2014.06.057

Reference yield:

benzylamine (100-46-9) → N1-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N4-(phenylmethyl)succinamide (1621317-95-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene / 1 h / 0 °C

2.1: triethylamine / tetrahydrofuran / 0.08 h / Cooling with ice

2.2: 0.25 h

2.3: 24 h / 20 °C

With triethylamine; In tetrahydrofuran; toluene;

DOI:10.1016/j.ejmech.2014.06.057

Reference yield:

C12H8ClN3O4S (1621317-72-3) → N1-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N4-(phenylmethyl)succinamide (1621317-95-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 0.5 h / 160 °C

2.1: hydrazine hydrate / N,N-dimethyl-formamide / 24 h / 20 °C

3.1: triethylamine / tetrahydrofuran / 0.08 h / Cooling with ice

3.2: 0.25 h

3.3: 24 h / 20 °C

With hydrazine hydrate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2014.06.057

upstream raw materials:

C₁₂H₈ClN₃O₄S

benzylamine

ethyl (3-amino-5-nitrobenzothiophen)-2-carboxylate

4-oxo-4-[(phenylmethyl)amino]butanoic acid

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