(1R,2R)-1-[N-(tert-butoxycarbonyl)amino]-1-phenyl-2-propyl 4-nitrobenzoate

Base Information

Chemical Name:(1R,2R)-1-[N-(tert-butoxycarbonyl)amino]-1-phenyl-2-propyl 4-nitrobenzoate
CAS No.:255060-80-1
Molecular Formula:C₂₁H₂₄N₂O₆
Molecular Weight:400.431
Hs Code.:

Synonyms:(1R,2R)-1-[N-(tert-butoxycarbonyl)amino]-1-phenyl-2-propyl 4-nitrobenzoate

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Chemical Property of (1R,2R)-1-[N-(tert-butoxycarbonyl)amino]-1-phenyl-2-propyl 4-nitrobenzoate

Chemical Property:

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Technology Process of (1R,2R)-1-[N-(tert-butoxycarbonyl)amino]-1-phenyl-2-propyl 4-nitrobenzoate

There total 5 articles about (1R,2R)-1-[N-(tert-butoxycarbonyl)amino]-1-phenyl-2-propyl 4-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 255060-79-8
(1R,2S)-1-[N-(tert-butoxycarbonyl)amino]-1-phenylpropan-2-ol

: 62-23-7
4-nitro-benzoic acid

: 255060-80-1
(1R,2R)-1-[N-(tert-butoxycarbonyl)amino]-1-phenyl-2-propyl 4-nitrobenzoate

Guidance literature:: With triphenylphosphine-cyclic sulfamide betaine; In toluene; at 20 ℃; for 17h;
DOI:10.1021/jm9910021

Reference yield:

: 255060-78-7
(-)-(1R,2S)-1-azido-1-phenyl-2-propanol

: 255060-80-1
(1R,2R)-1-[N-(tert-butoxycarbonyl)amino]-1-phenyl-2-propyl 4-nitrobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / H₂; aq. HCl / 10 percent Pd/C / ethanol / 16 h / 2585.74 Torr

2: 86 percent / Et₃N / CH₂Cl₂ / 1 h / 20 °C

3: 25 percent / triphenylphosphine-cyclic sulfamide betaine / toluene / 17 h / 20 °C

With hydrogenchloride; triphenylphosphine-cyclic sulfamide betaine; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; toluene; 1: Reduction / 2: Acylation / 3: Esterification;
DOI:10.1021/jm9910021

Reference yield:

: 4518-66-5
(1S,2S)-(-)-1-phenyl-1-propene oxide

: 255060-80-1
(1R,2R)-1-[N-(tert-butoxycarbonyl)amino]-1-phenyl-2-propyl 4-nitrobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / NaN₃; NH₄Cl / ethanol; H₂O / 2 h / Heating

2: 79 percent / H₂; aq. HCl / 10 percent Pd/C / ethanol / 16 h / 2585.74 Torr

3: 86 percent / Et₃N / CH₂Cl₂ / 1 h / 20 °C

4: 25 percent / triphenylphosphine-cyclic sulfamide betaine / toluene / 17 h / 20 °C

With hydrogenchloride; sodium azide; triphenylphosphine-cyclic sulfamide betaine; hydrogen; ammonium chloride; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; water; toluene; 1: Ring cleavage / 2: Reduction / 3: Acylation / 4: Esterification;
DOI:10.1021/jm9910021