t-butyl 5-benzyloxy-2-methyl indole acetate

Base Information

• Chemical Name: t-butyl 5-benzyloxy-2-methyl indole acetate
• CAS No.: 346424-35-9
• Molecular Formula: C₂₂H₂₅NO₃
• Molecular Weight: 351.445
• Mol file: 346424-35-9.mol

Synonyms:t-butyl 5-benzyloxy-2-methyl indole acetate

Chemical Property of t-butyl 5-benzyloxy-2-methyl indole acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of t-butyl 5-benzyloxy-2-methyl indole acetate

There total 1 articles about t-butyl 5-benzyloxy-2-methyl indole acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

levulinic acid t-butyl ester (2854-10-6) + 4-benzyloxyphenylhydrazine hydrochloride (52068-30-1,55974-70-4) → t-butyl 5-benzyloxy-2-methyl indole acetate (346424-35-9)

Guidance literature:

With sodium acetate; In acetic acid; for 2h; Heating;

DOI:10.1021/jm000483h

Reference yield: 100.0%

4-chloro-benzoyl chloride (122-01-0) + t-butyl 5-benzyloxy-2-methyl indole acetate (346424-35-9) → t-butyl 5-benzyloxy-1-(chlorobenzoyl)-2-methyl indole acetate

Guidance literature:

t-butyl 5-benzyloxy-2-methyl indole acetate; With potassium tert-butylate; In tetrahydrofuran; for 0.333333h;

4-chloro-benzoyl chloride; In tetrahydrofuran; for 11h; Further stages.;

DOI:10.1021/jm000483h

Reference yield: 51.0%

1-(1-Bromo-3-phenyl-propyl)-4-chloro-benzene + t-butyl 5-benzyloxy-2-methyl indole acetate (346424-35-9) → t-butyl-5-benzyloxy-1-[1-(4-chlorophenyl)-3-phenyl-propyl]-2-methyl indole 3-acetate

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 14h;

DOI:10.1021/jm000483h

upstream raw materials:

levulinic acid t-butyl ester

4-benzyloxyphenylhydrazine hydrochloride

Downstream raw materials:

O-Desmethyl-Indomethacin

[1-(4-chloro-benzoyl)-5-hydroxy-2-methyl-1H-indol-3-yl]-acetic acid tert-butyl ester

5-methyl-hexanoic acid 3-tert-butoxycarbonylmethyl-1-(4-chloro-benzoyl)-2-methyl-1H-indol-5-yl ester