N-cyclobutyl-N'-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}sulfamide

Base Information

Chemical Name:N-cyclobutyl-N'-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}sulfamide
CAS No.:1262786-36-6
Molecular Formula:C₂₉H₃₉N₅O₂S
Molecular Weight:521.727
Hs Code.:

Synonyms:N-cyclobutyl-N'-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}sulfamide

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Chemical Property of N-cyclobutyl-N'-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}sulfamide

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Technology Process of N-cyclobutyl-N'-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}sulfamide

There total 6 articles about N-cyclobutyl-N'-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}sulfamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1262786-55-9
4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenyl-1-butanamine

: 1262786-69-5
N-cyclobutyl-2-oxo-1,3-oxazolidine-3-sulfonamide

: 1262786-36-6
N-cyclobutyl-N'-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}sulfamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 80 ℃; for 5h;

Reference yield:

: 29940-88-3
4-oxo-2-phenyl-butyronitrile

: 1262786-36-6
N-cyclobutyl-N'-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}sulfamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 20 °C / Inert atmosphere

2: hydrogen; ammonia / Raney Nickel / ethanol; water / 18 h / 2585.81 Torr / Fischer-Porter apparatus

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 h / 80 °C

With ammonia; hydrogen; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; Raney Nickel; In ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 5292-53-5
diethyl benzalmalonate

: 1262786-36-6
N-cyclobutyl-N'-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}sulfamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: water / ethanol / 18 h / 70 °C

2.1: lithium borohydride / tetrahydrofuran / 2 h / 65 °C / Inert atmosphere

2.2: 0.17 h / 20 °C

3.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere

4.1: sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 20 °C / Inert atmosphere

5.1: hydrogen; ammonia / Raney Nickel / ethanol; water / 18 h / 2585.81 Torr / Fischer-Porter apparatus

6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 h / 80 °C

With lithium borohydride; ammonia; water; hydrogen; sodium tris(acetoxy)borohydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; Raney Nickel; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;