4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenyl-1-butanamine

Base Information

Chemical Name:4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenyl-1-butanamine
CAS No.:1262786-55-9
Molecular Formula:C₂₅H₃₂N₄
Molecular Weight:388.556
Hs Code.:

Synonyms:4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenyl-1-butanamine

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Chemical Property of 4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenyl-1-butanamine

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Technology Process of 4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenyl-1-butanamine

There total 5 articles about 4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenyl-1-butanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1262786-54-8
4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutanenitrile

: 1262786-55-9
4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenyl-1-butanamine

Guidance literature:: With ammonium hydroxide; hydrogen; In ethanol; at 20 ℃; for 18h; under 2585.81 Torr;
DOI:10.1016/j.bmcl.2011.01.030

Reference yield:

: 14025-83-3
3-cyano-3-phenylpropanoic acid ethyl ester

: 1262786-55-9
4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenyl-1-butanamine

Guidance literature:: Multi-step reaction with 4 steps

1: lithium borohydride / tetrahydrofuran / 2 h / Reflux

2: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

3: sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 20 °C

4: ammonium hydroxide; hydrogen / ethanol / 18 h / 20 °C / 2585.81 Torr

With ammonium hydroxide; lithium borohydride; hydrogen; sodium tris(acetoxy)borohydride; Dess-Martin periodane; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.01.030

Reference yield:

: 29940-88-3
4-oxo-2-phenyl-butyronitrile

: 1262786-55-9
4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenyl-1-butanamine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 20 °C

2: ammonium hydroxide; hydrogen / ethanol / 18 h / 20 °C / 2585.81 Torr

With ammonium hydroxide; hydrogen; sodium tris(acetoxy)borohydride; In ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.01.030