4-Methyl-D-phenylalanine

Base Information

• Chemical Name: 4-Methyl-D-phenylalanine
• CAS No.: 49759-61-7
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.219
• Hs Code.: 2922498590
• Mol file: 49759-61-7.mol

Synonyms:D-4-Methylphenylalanine;D-4'-Methylphenylalanine;p-Methyl-D-phenylalanine;(2R)-2-Amino-3-(4-methylphenyl)propanoic acid;

Chemical Property of 4-Methyl-D-phenylalanine

Chemical Property:

• Boiling Point: 323.5 °C at 760 mmHg
• Flash Point: 149.5 °C
• PSA: 63.32000
• Density: 1.165 g/cm³
• LogP: 1.64970
• Storage Temp.: Store at RT.

Purity/Quality:

97% ^*data from raw suppliers

4-Methyl-D-phenylalanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Methyl-D-phenylalanine is a derivative of D-Phenylalanine (P319410) and is used as a reagent in the synthesis of aminophenylpropanyl phosphate derivatives which can exhibit pin1 inhibitory activity.

Technology Process of 4-Methyl-D-phenylalanine

There total 28 articles about 4-Methyl-D-phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(S)-2-Acetylamino-3-p-tolyl-propionic acid (74046-14-3) → 4-methyl-L-phenylalanine (1991-87-3,4599-47-7,7758-37-4,49759-61-7)

Guidance literature:

With Acylase I enzyme from porcine kidney; water; at 24.9 ℃; Rate constant;

DOI:10.1016/S0040-4039(98)00997-6

Reference yield: 46.0%

p-methylphenylalanine (4599-47-7) → 4-methyl-L-phenylalanine (1991-87-3,4599-47-7,7758-37-4,49759-61-7)

Guidance literature:

With sodium hydroxide; oxygen; at 30 ℃; for 43h; pH=7.3; optical yield given as %ee; enantioselective reaction; aq. buffer; Enzymatic reaction;

DOI:10.1016/j.bmcl.2008.12.100

Reference yield:

2-oxo-3-(p-tolyl)propanoic acid (38335-22-7) + 2,2-diphenylglycine (3060-50-2) → benzophenone (119-61-9) + 4-methyl-L-phenylalanine (1991-87-3,4599-47-7,7758-37-4,49759-61-7) + (R)-2-amino-3-(4-methylphenyl)propionic acid

Guidance literature:

With C₃₉H₃₃N₃O₂*2ClH; In methanol; water; at 20 ℃; for 72h; enantioselective reaction;

DOI:10.1016/j.tetlet.2016.09.005

upstream raw materials:

(S)-2-Benzyloxycarbonylamino-3-p-tolyl-propionic acid

N-acetyl-4-methyl-phenylalanine

(S)-2-Acetylamino-3-p-tolyl-propionic acid

3-(4-methylphenyl)-2-oxopropanoic acid

Downstream raw materials:

(S)-2-(2-Nitro-phenylsulfanylamino)-3-p-tolyl-propionic acid

(S)-2-Acetylamino-3-p-tolyl-propionic acid

3-(4-hydroxy-3-methylphenyl)-L-alanine

L-(p-hydroxymethyl)phenylalanine