4,5-Dichloro-2-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-benzoic acid (S)-3-(4-methoxy-phenyl)-1-methyl-prop-2-ynyl ester

Base Information

• Chemical Name: 4,5-Dichloro-2-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-benzoic acid (S)-3-(4-methoxy-phenyl)-1-methyl-prop-2-ynyl ester
• CAS No.: 865266-03-1
• Molecular Formula: C₂₉H₂₉Cl₂NO₆S
• Molecular Weight: 590.524

Synonyms:4,5-Dichloro-2-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-benzoic acid (S)-3-(4-methoxy-phenyl)-1-methyl-prop-2-ynyl ester

Chemical Property of 4,5-Dichloro-2-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-benzoic acid (S)-3-(4-methoxy-phenyl)-1-methyl-prop-2-ynyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,5-Dichloro-2-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-benzoic acid (S)-3-(4-methoxy-phenyl)-1-methyl-prop-2-ynyl ester

There total 3 articles about 4,5-Dichloro-2-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-benzoic acid (S)-3-(4-methoxy-phenyl)-1-methyl-prop-2-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

4-(4-methoxyphenyl)but-3-yn-2-ol (111887-18-4) + (1S,2R,4R)-N-(2-carboxy-4,5-dichlorobenzoyl)-10,2-camphorsultam (193202-37-8) → 4,5-Dichloro-2-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-benzoic acid (R)-3-(4-methoxy-phenyl)-1-methyl-prop-2-ynyl ester + 4,5-Dichloro-2-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-benzoic acid (S)-3-(4-methoxy-phenyl)-1-methyl-prop-2-ynyl ester (865266-03-1)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;

DOI:10.1007/s00706-005-0281-3

Reference yield:

1-(2,2-dibromovinyl)-4-methoxybenzene (60512-57-4) → 4,5-Dichloro-2-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-benzoic acid (S)-3-(4-methoxy-phenyl)-1-methyl-prop-2-ynyl ester (865266-03-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C

1.2: 79 percent / tetrahydrofuran / 0.33 h / 20 °C

2.1: 49 percent / 1,3-dicyclohexylcarbodiimide; 4-dimethylaminopyridine / CH₂Cl₂ / 20 °C

With dmap; n-butyllithium; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;

DOI:10.1007/s00706-005-0281-3

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → 4,5-Dichloro-2-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-benzoic acid (S)-3-(4-methoxy-phenyl)-1-methyl-prop-2-ynyl ester (865266-03-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 99 percent / PPh₃ / CH₂Cl₂ / 0.17 h / 20 °C

2.1: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C

2.2: 79 percent / tetrahydrofuran / 0.33 h / 20 °C

3.1: 49 percent / 1,3-dicyclohexylcarbodiimide; 4-dimethylaminopyridine / CH₂Cl₂ / 20 °C

With dmap; n-butyllithium; dicyclohexyl-carbodiimide; triphenylphosphine; In tetrahydrofuran; dichloromethane;

DOI:10.1007/s00706-005-0281-3

upstream raw materials:

4-(4-methoxyphenyl)but-3-yn-2-ol

(1S,2R,4R)-N-(2-carboxy-4,5-dichlorobenzoyl)-10,2-camphorsultam

1-(2,2-dibromovinyl)-4-methoxybenzene

4-methoxy-benzaldehyde

Downstream raw materials:

(S)-(-)-4-(4-methoxyphenyl)-3-butyn-2-ol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 865266-03-1 4,5-Dichloro-2-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-benzoic acid (S)-3-(4-methoxy-phenyl)-1-methyl-prop-2-ynyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send