(2E,2′E)-N,N′-(Propane-1,3-diyl)bis(2-(3-hydroxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene) propanamide)

Base Information

Chemical Name:(2E,2′E)-N,N′-(Propane-1,3-diyl)bis(2-(3-hydroxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene) propanamide)
CAS No.:1415681-26-3
Molecular Formula:C₃₁H₃₀N₂O₁₀
Molecular Weight:590.587
Hs Code.:

Synonyms:(2E,2′E)-N,N′-(Propane-1,3-diyl)bis(2-(3-hydroxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene) propanamide)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2E,2′E)-N,N′-(Propane-1,3-diyl)bis(2-(3-hydroxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene) propanamide)

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Technology Process of (2E,2′E)-N,N′-(Propane-1,3-diyl)bis(2-(3-hydroxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene) propanamide)

There total 5 articles about (2E,2′E)-N,N′-(Propane-1,3-diyl)bis(2-(3-hydroxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene) propanamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1092557-61-3
3-(4-methoxyphenyl)-6-methylfuro[3,2-b]furan-2,5-dione

: 109-76-2,54018-94-9
Trimethylenediamine

: 1415681-26-3
(2E,2′E)-N,N′-(Propane-1,3-diyl)bis(2-(3-hydroxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene) propanamide)

Guidance literature:: 3-(4-methoxyphenyl)-6-methylfuro[3,2-b]furan-2,5-dione; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at -35 ℃; for 0.25h;

Trimethylenediamine; In tetrahydrofuran; at -78 ℃; for 0.25h;
DOI:10.1016/j.ica.2012.08.009

Reference yield:

: 58368-11-9
4-Methoxy-3-(4-methoxyphenyl)-furan-2(5H)-one

: 1415681-26-3
(2E,2′E)-N,N′-(Propane-1,3-diyl)bis(2-(3-hydroxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene) propanamide)

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisopropylamine; n-butyllithium; ammonium chloride; triethylamine; dmap; trifluoroacetic anhydride / tetrahydrofuran; dichloromethane

2.1: magnesium bromide / N,N-dimethyl-formamide / 120 °C

3.1: acetic anhydride / acetic anhydride / 1 h / Reflux

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.25 h / -35 °C

4.2: 0.25 h / -78 °C

With dmap; n-butyllithium; ammonium chloride; tetrabutyl ammonium fluoride; acetic anhydride; triethylamine; diisopropylamine; trifluoroacetic anhydride; magnesium bromide; In tetrahydrofuran; dichloromethane; acetic anhydride; N,N-dimethyl-formamide;
DOI:10.1016/j.ica.2012.08.009

Reference yield:

: 1146510-10-2
Methyl 2-(3-methoxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene)-propanoate

: 1415681-26-3
(2E,2′E)-N,N′-(Propane-1,3-diyl)bis(2-(3-hydroxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene) propanamide)

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium bromide / N,N-dimethyl-formamide / 120 °C

2.1: acetic anhydride / acetic anhydride / 1 h / Reflux

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.25 h / -35 °C

3.2: 0.25 h / -78 °C

With tetrabutyl ammonium fluoride; acetic anhydride; magnesium bromide; In tetrahydrofuran; acetic anhydride; N,N-dimethyl-formamide;
DOI:10.1016/j.ica.2012.08.009