(1R,3S,5S)-2,4-Dibenzyl-1,8,8-trimethyl-3-phenoxy-2,4-diaza-3-phospha-bicyclo[3.2.1]octane 3-oxide

Base Information

Chemical Name:(1R,3S,5S)-2,4-Dibenzyl-1,8,8-trimethyl-3-phenoxy-2,4-diaza-3-phospha-bicyclo[3.2.1]octane 3-oxide
CAS No.:696660-32-9
Molecular Formula:C₂₈H₃₃N₂O₂P
Molecular Weight:460.556
Hs Code.:

Synonyms:(1R,3S,5S)-2,4-Dibenzyl-1,8,8-trimethyl-3-phenoxy-2,4-diaza-3-phospha-bicyclo[3.2.1]octane 3-oxide

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Chemical Property of (1R,3S,5S)-2,4-Dibenzyl-1,8,8-trimethyl-3-phenoxy-2,4-diaza-3-phospha-bicyclo[3.2.1]octane 3-oxide

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Technology Process of (1R,3S,5S)-2,4-Dibenzyl-1,8,8-trimethyl-3-phenoxy-2,4-diaza-3-phospha-bicyclo[3.2.1]octane 3-oxide

There total 5 articles about (1R,3S,5S)-2,4-Dibenzyl-1,8,8-trimethyl-3-phenoxy-2,4-diaza-3-phospha-bicyclo[3.2.1]octane 3-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 770-12-7
O-phenyl phosphorodichloridate

: 752232-62-5
(+)-cis-N,N'-dibenzyl-1,2,2-trimethylcyclopentane-1,3-diamine

: 696660-32-9
(1R,3S,5S)-2,4-Dibenzyl-1,8,8-trimethyl-3-phenoxy-2,4-diaza-3-phospha-bicyclo[3.2.1]octane 3-oxide

: (1R,3R,5S)-2,4-Dibenzyl-1,8,8-trimethyl-3-phenoxy-2,4-diaza-3-phospha-bicyclo[3.2.1]octane 3-oxide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/j.tet.2004.08.082

Reference yield:

: 124-83-4
D-(+)-camphoric acid

: 696660-32-9
(1R,3S,5S)-2,4-Dibenzyl-1,8,8-trimethyl-3-phenoxy-2,4-diaza-3-phospha-bicyclo[3.2.1]octane 3-oxide

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / sodium azide; sulfuric acid

2: 89 percent / p-toluenesulfonic acid / toluene / 8 h / 80 °C

3: 68 percent / sodium borohydride / CHCl₃ / 10 h / 60 - 65 °C

4: 55 percent / triethylamine / CH₂Cl₂ / 24 h / 20 °C

With sodium tetrahydroborate; sodium azide; sulfuric acid; toluene-4-sulfonic acid; triethylamine; In dichloromethane; chloroform; toluene;
DOI:10.1016/j.tet.2004.08.082

Reference yield:

: 116481-14-2
(1R,3S)-1,2,2-trimethyl-1,3-cyclopentanediamine

: 696660-32-9
(1R,3S,5S)-2,4-Dibenzyl-1,8,8-trimethyl-3-phenoxy-2,4-diaza-3-phospha-bicyclo[3.2.1]octane 3-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / p-toluenesulfonic acid / toluene / 8 h / 80 °C

2: 68 percent / sodium borohydride / CHCl₃ / 10 h / 60 - 65 °C

3: 55 percent / triethylamine / CH₂Cl₂ / 24 h / 20 °C

With sodium tetrahydroborate; toluene-4-sulfonic acid; triethylamine; In dichloromethane; chloroform; toluene;
DOI:10.1016/j.tet.2004.08.082