3-({3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-trimethylsilanyloxy-methylsulfanyl)-N,N-dimethyl-propionamide

Base Information

• Chemical Name: 3-({3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-trimethylsilanyloxy-methylsulfanyl)-N,N-dimethyl-propionamide
• CAS No.: 120578-06-5
• Molecular Formula: C₂₆H₃₁ClN₂O₂SSi
• Molecular Weight: 499.149
• Mol file: 120578-06-5.mol

Synonyms:3-({3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-trimethylsilanyloxy-methylsulfanyl)-N,N-dimethyl-propionamide

Chemical Property of 3-({3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-trimethylsilanyloxy-methylsulfanyl)-N,N-dimethyl-propionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-({3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-trimethylsilanyloxy-methylsulfanyl)-N,N-dimethyl-propionamide

There total 4 articles about 3-({3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-trimethylsilanyloxy-methylsulfanyl)-N,N-dimethyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde (120578-03-2) + N,N-dimethyl-3-mercaptopropionamide (92065-71-9) + 1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) → 3-({3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-trimethylsilanyloxy-methylsulfanyl)-N,N-dimethyl-propionamide (120578-06-5)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 12 - 14 ℃; for 24h;

DOI:10.1021/jo00276a038

Reference yield:

2-methyl-7-chloroquinoline (4965-33-7) → 3-({3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-trimethylsilanyloxy-methylsulfanyl)-N,N-dimethyl-propionamide (120578-06-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) acetic anhydride, 2.) acetic acid / 1.) xylene, reflux, 7 h, 2.) reflux

2: imidazole / CH₂Cl₂ / 24 h / 12 - 14 °C

With 1H-imidazole; acetic anhydride; acetic acid; In dichloromethane;

DOI:10.1021/jo00276a038

Reference yield:

Isophthalaldehyde (626-19-7) → 3-({3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-trimethylsilanyloxy-methylsulfanyl)-N,N-dimethyl-propionamide (120578-06-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) acetic anhydride, 2.) acetic acid / 1.) xylene, reflux, 7 h, 2.) reflux

2: imidazole / CH₂Cl₂ / 24 h / 12 - 14 °C

With 1H-imidazole; acetic anhydride; acetic acid; In dichloromethane;

DOI:10.1021/jo00276a038

upstream raw materials:

(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde

N,N-dimethyl-3-mercaptopropionamide

1,1,1,3,3,3-hexamethyl-disilazane

2-methyl-7-chloroquinoline

Downstream raw materials:

dimethyl 5-<3-<2-(7-chloro-2-quinolinyl)-(E)-ethenyl>phenyl>-4,6-dithianonanedioate

(+)-methyl 5-(3-(2-(7-chloroquinoline-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoate

3-[{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-(2-dimethylcarbamoyl-ethylsulfanyl)-methylsulfanyl]-N,N-dimethyl-propionamide

(E)-5-(3-(2-(7-chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoic acid