(E)-3-(3-Cyclopentyloxy-4-methoxy-phenyl)-acryloyl chloride

Base Information

• Chemical Name: (E)-3-(3-Cyclopentyloxy-4-methoxy-phenyl)-acryloyl chloride
• CAS No.: 162544-53-8
• Molecular Formula: C₁₅H₁₇ClO₃
• Molecular Weight: 280.751
• Mol file: 162544-53-8.mol

Synonyms:(E)-3-(3-Cyclopentyloxy-4-methoxy-phenyl)-acryloyl chloride

Chemical Property of (E)-3-(3-Cyclopentyloxy-4-methoxy-phenyl)-acryloyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-(3-Cyclopentyloxy-4-methoxy-phenyl)-acryloyl chloride

There total 5 articles about (E)-3-(3-Cyclopentyloxy-4-methoxy-phenyl)-acryloyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-(3-cyclopentyloxy-4-methoxyphenyl)-2-propenoic acid (133332-31-7,145743-83-5) → (E)-3-(3-Cyclopentyloxy-4-methoxy-phenyl)-acryloyl chloride (162544-53-8)

Guidance literature:

With thionyl chloride; In toluene; at 95 ℃; for 2.5h;

DOI:10.1080/00397919708004171

Reference yield:

3-cyclopentyloxy-4-methoxybenzylaldehyde (67387-76-2) → (E)-3-(3-Cyclopentyloxy-4-methoxy-phenyl)-acryloyl chloride (162544-53-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride; ethyl phosphate / 1,2-dimethoxy-ethane / 4 h / 20 °C

1.2: 91 percent / 1,2-dimethoxy-ethane / 24 h / 20 °C

2.1: oxalyl chloride / CH₂Cl₂ / 0 - 20 °C

With oxalyl dichloride; triethyl phosphate; sodium hydride; In 1,2-dimethoxyethane; dichloromethane;

DOI:10.1021/ja027313+

Reference yield:

isovanillin (621-59-0) → (E)-3-(3-Cyclopentyloxy-4-methoxy-phenyl)-acryloyl chloride (162544-53-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 81 percent / potassium carbonate / acetone / 96 h / Heating

2.1: sodium hydride; ethyl phosphate / 1,2-dimethoxy-ethane / 4 h / 20 °C

2.2: 91 percent / 1,2-dimethoxy-ethane / 24 h / 20 °C

3.1: oxalyl chloride / CH₂Cl₂ / 0 - 20 °C

With oxalyl dichloride; triethyl phosphate; sodium hydride; potassium carbonate; In 1,2-dimethoxyethane; dichloromethane; acetone;

DOI:10.1021/ja027313+

upstream raw materials:

(E)-3-(3-cyclopentyloxy-4-methoxyphenyl)-2-propenoic acid

isovanillin

Cyclopentyl bromide

3-cyclopentyloxy-4-methoxybenzylaldehyde

Downstream raw materials:

(E)-1-[3-(3-cyclopentyloxy-4-methoxyphenyl)-2-propenoyl]-3,5-dimethyl-pyrazole

(R)-2-(3-Cyclopentyloxy-4-methoxy-phenyl)-3-((R)-4-phenyl-4,5-dihydro-oxazol-2-yl)-propionitrile

(2R,4R)-2-[4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolin-2-yl]amino-2-phenylethanol

(4R)-2-(E)-[2-(3-cyclopentyloxy-4-methoxyphenyl)ethenyl]-4-phenyl-4,5-dihydroxyoxazole