Technology Process of L-Tyr-L-Leu-OH trifluoroacetate
There total 2 articles about L-Tyr-L-Leu-OH trifluoroacetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-chlorotrityl-leucine resin; Fmoc-DL-Tyr-OH;
With
N-(4,6-dimethoxy-1,3,5-triazin-2-yl)strychninium tetrafluoroborate; strychnidin-10-one;
In
acetonitrile;
at 0 ℃;
for 1.25h;
Wang resin
With
piperidine;
In
N,N-dimethyl-formamide;
for 0.166667h;
Wang resin
trifluoroacetic acid;
With
triethylsilane; water;
for 2h;
Wang resin
DOI:10.1002/hlca.201200426
- Guidance literature:
-
Fmoc-Leu-Wang resin;
With
piperidine;
In
N,N-dimethyl-formamide;
Wang resin
N-Fmoc-Tyr-OH;
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; ethyl cyanoglyoxylate-2-oxime;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 1h;
Wang resin
trifluoroacetic acid;
Further stages;
DOI:10.1002/anie.201806966
- Guidance literature:
-
L-Tyr-L-Leu-OH trifluoroacetate;
With
N-fluorobis(benzenesulfon)imide;
In
water; acetonitrile;
for 6h;
UV-irradiation;
trifluoroacetic acid;
In
water; acetonitrile;
DOI:10.1021/jacs.6b11533
