ethyl 1-(6-(2-(4-hydroxyphenethyl)phenyl)pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

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Chemical Name:ethyl 1-(6-(2-(4-hydroxyphenethyl)phenyl)pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
CAS No.:1305197-88-9
Molecular Formula:C₂₆H₂₂F₃N₃O₃
Molecular Weight:481.474
Hs Code.:

Synonyms:ethyl 1-(6-(2-(4-hydroxyphenethyl)phenyl)pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

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Chemical Property of ethyl 1-(6-(2-(4-hydroxyphenethyl)phenyl)pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

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Technology Process of ethyl 1-(6-(2-(4-hydroxyphenethyl)phenyl)pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

There total 6 articles about ethyl 1-(6-(2-(4-hydroxyphenethyl)phenyl)pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1128269-45-3
ethyl 1-(6-(2-(4-methoxyphenethyl)phenyl)pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

: 1305197-88-9
ethyl 1-(6-(2-(4-hydroxyphenethyl)phenyl)pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Guidance literature:: With boron tribromide; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 40138-16-7
2-formylbenzene boronic acid

: 1305197-88-9
ethyl 1-(6-(2-(4-hydroxyphenethyl)phenyl)pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 4 h / 110 °C

2.1: sodium hydride / tetrahydrofuran / 2 h / 20 °C

2.2: 20 - 50 °C

3.1: sulfuric acid / 80 °C

4.1: palladium 10% on activated carbon; hydrogen / methanol / 40 °C / 750.08 Torr

5.1: boron tribromide / dichloromethane / 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; palladium 10% on activated carbon; hydrogen; boron tribromide; sodium hydride; sodium carbonate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: ethyl 1-(6-(2-formylphenyl)pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

: 1305197-88-9
ethyl 1-(6-(2-(4-hydroxyphenethyl)phenyl)pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 2 h / 20 °C

1.2: 20 - 50 °C

2.1: sulfuric acid / 80 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol / 40 °C / 750.08 Torr

4.1: boron tribromide / dichloromethane / 0 - 20 °C

With sulfuric acid; palladium 10% on activated carbon; hydrogen; boron tribromide; sodium hydride; In tetrahydrofuran; methanol; dichloromethane;