(2-((7-chloroquinolin-4-ylamino)methyl)-4-phenylthiazol-5-yl)(pyrrolidin-1-yl)methanone

Base Information

Chemical Name:(2-((7-chloroquinolin-4-ylamino)methyl)-4-phenylthiazol-5-yl)(pyrrolidin-1-yl)methanone
CAS No.:1404113-54-7
Molecular Formula:C₂₄H₂₁ClN₄OS
Molecular Weight:448.976
Hs Code.:

Synonyms:(2-((7-chloroquinolin-4-ylamino)methyl)-4-phenylthiazol-5-yl)(pyrrolidin-1-yl)methanone

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Chemical Property of (2-((7-chloroquinolin-4-ylamino)methyl)-4-phenylthiazol-5-yl)(pyrrolidin-1-yl)methanone

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Technology Process of (2-((7-chloroquinolin-4-ylamino)methyl)-4-phenylthiazol-5-yl)(pyrrolidin-1-yl)methanone

There total 4 articles about (2-((7-chloroquinolin-4-ylamino)methyl)-4-phenylthiazol-5-yl)(pyrrolidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55919-47-6
ethyl 2-bromo-3-oxo-3-phenylpropionate

: 1404113-54-7
(2-((7-chloroquinolin-4-ylamino)methyl)-4-phenylthiazol-5-yl)(pyrrolidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol; N,N-dimethyl-formamide / 2 h / 80 °C

2: hydrogen bromide / acetic acid / 3 h / 20 °C

3: phenol / 3 h / 130 °C / Inert atmosphere

4: water / ethanol; water / 1.5 h / Reflux

5: triethanolamine; benzotriazol-1-ol; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 0.67 h / 20 - 55 °C / Microwave irradiation

With triethanolamine; water; hydrogen bromide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; phenol; In ethanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.07.040

Reference yield:

: 1404113-51-4
C₁₃H₁₄N₂O₂S

: 1404113-54-7
(2-((7-chloroquinolin-4-ylamino)methyl)-4-phenylthiazol-5-yl)(pyrrolidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: phenol / 3 h / 130 °C / Inert atmosphere

2: water / ethanol; water / 1.5 h / Reflux

3: triethanolamine; benzotriazol-1-ol; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 0.67 h / 20 - 55 °C / Microwave irradiation

With triethanolamine; water; benzotriazol-1-ol; dicyclohexyl-carbodiimide; phenol; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.07.040

Reference yield:

: 1404113-52-5
ethyl 2-((7-chloroquinolin-4-ylamino)methyl)-4-phenylthiazole-5-carboxylate

: 1404113-54-7
(2-((7-chloroquinolin-4-ylamino)methyl)-4-phenylthiazol-5-yl)(pyrrolidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: water / ethanol; water / 1.5 h / Reflux

2: triethanolamine; benzotriazol-1-ol; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 0.67 h / 20 - 55 °C / Microwave irradiation

With triethanolamine; water; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.07.040