ethyl 2-((7-chloroquinolin-4-ylamino)methyl)-4-phenylthiazole-5-carboxylate

Base Information

Chemical Name:ethyl 2-((7-chloroquinolin-4-ylamino)methyl)-4-phenylthiazole-5-carboxylate
CAS No.:1404113-52-5
Molecular Formula:C₂₂H₁₈ClN₃O₂S
Molecular Weight:423.923
Hs Code.:

Synonyms:ethyl 2-((7-chloroquinolin-4-ylamino)methyl)-4-phenylthiazole-5-carboxylate

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Chemical Property of ethyl 2-((7-chloroquinolin-4-ylamino)methyl)-4-phenylthiazole-5-carboxylate

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Technology Process of ethyl 2-((7-chloroquinolin-4-ylamino)methyl)-4-phenylthiazole-5-carboxylate

There total 3 articles about ethyl 2-((7-chloroquinolin-4-ylamino)methyl)-4-phenylthiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 86-98-6,1138471-54-1
4,7-dichloroquinoline

: 1404113-51-4
C₁₃H₁₄N₂O₂S

: 1404113-52-5
ethyl 2-((7-chloroquinolin-4-ylamino)methyl)-4-phenylthiazole-5-carboxylate

Guidance literature:: With phenol; at 130 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.07.040

Reference yield:

: 55919-47-6
ethyl 2-bromo-3-oxo-3-phenylpropionate

: 1404113-52-5
ethyl 2-((7-chloroquinolin-4-ylamino)methyl)-4-phenylthiazole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol; N,N-dimethyl-formamide / 2 h / 80 °C

2: hydrogen bromide / acetic acid / 3 h / 20 °C

3: phenol / 3 h / 130 °C / Inert atmosphere

With hydrogen bromide; phenol; In ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.07.040

Reference yield:

: 1404113-50-3
ethyl 2-((benzyloxycarbonylamino)methyl)-4-phenylthiazole-5-carboxylate

: 1404113-52-5
ethyl 2-((7-chloroquinolin-4-ylamino)methyl)-4-phenylthiazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen bromide / acetic acid / 3 h / 20 °C

2: phenol / 3 h / 130 °C / Inert atmosphere

With hydrogen bromide; phenol; In acetic acid;
DOI:10.1016/j.bmc.2012.07.040