(+/-)-9-[(1 RS)-2,2-di(benzyloxymethyl)-3,3-difluoro-cyclopropylmethyl]-9H-6-purinamine

Base Information

Chemical Name:(+/-)-9-[(1 RS)-2,2-di(benzyloxymethyl)-3,3-difluoro-cyclopropylmethyl]-9H-6-purinamine
CAS No.:220825-89-8
Molecular Formula:C₂₅H₂₅F₂N₅O₂
Molecular Weight:465.503
Hs Code.:

Synonyms:(+/-)-9-[(1 RS)-2,2-di(benzyloxymethyl)-3,3-difluoro-cyclopropylmethyl]-9H-6-purinamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-9-[(1 RS)-2,2-di(benzyloxymethyl)-3,3-difluoro-cyclopropylmethyl]-9H-6-purinamine

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Technology Process of (+/-)-9-[(1 RS)-2,2-di(benzyloxymethyl)-3,3-difluoro-cyclopropylmethyl]-9H-6-purinamine

There total 7 articles about (+/-)-9-[(1 RS)-2,2-di(benzyloxymethyl)-3,3-difluoro-cyclopropylmethyl]-9H-6-purinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9
adenine

: 220825-78-5
(+/-)-(1 RS)-[2,2-di(benzyloxymethyl)-3,3-difluorocyclopropyl]-methanol

: 220825-89-8
(+/-)-9-[(1 RS)-2,2-di(benzyloxymethyl)-3,3-difluoro-cyclopropylmethyl]-9H-6-purinamine

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; at 20 ℃; for 12h;
DOI:10.1016/S0040-4020(98)01067-9

Reference yield:

: 6972-79-8
dibenzyl glycerol

: 220825-89-8
(+/-)-9-[(1 RS)-2,2-di(benzyloxymethyl)-3,3-difluoro-cyclopropylmethyl]-9H-6-purinamine

Guidance literature:: Multi-step reaction with 7 steps

1: 84 percent / 2,2,6,6-tetramethyl-piperidin-1-oxyl radical (TEMPO); KBr; NaOCl / CH₂Cl₂; H₂O / 1 h / 10 - 15 °C

2: 82 percent / NaH / various solvent(s)

3: 85 percent / diisobutyl aluminium hydride (DIBAH) / toluene / -40 °C

4: 84 percent / pyridine / 4 h / 25 °C

5: 75 percent / bis-(2-methoxy-ethyl) ether / 1 h / 190 °C

6: 91 percent / sodium methoxide / methanol / 0.5 h

7: 72 percent / triphenylphosphine (TPP); diethyl azodicarboxylate (DEAD) / dioxane / 12 h / 20 °C

With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydride; diisobutylaluminium hydride; triphenylphosphine; potassium bromide; diethylazodicarboxylate; sodium methylate; In 1,4-dioxane; pyridine; methanol; dichloromethane; diethylene glycol dimethyl ether; water; toluene; 1: Oxidation / 2: Wittig-reaction / 3: Alcohol formation / 4: Acetylation / 5: Cycloaddition / 6: Deacetylation / 7: Substitution;
DOI:10.1016/S0040-4020(98)01067-9

Reference yield:

: 77356-14-0
1,3-dibenzyloxy-2-propanone

: 220825-89-8
(+/-)-9-[(1 RS)-2,2-di(benzyloxymethyl)-3,3-difluoro-cyclopropylmethyl]-9H-6-purinamine

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / NaH / various solvent(s)

2: 85 percent / diisobutyl aluminium hydride (DIBAH) / toluene / -40 °C

3: 84 percent / pyridine / 4 h / 25 °C

4: 75 percent / bis-(2-methoxy-ethyl) ether / 1 h / 190 °C

5: 91 percent / sodium methoxide / methanol / 0.5 h

6: 72 percent / triphenylphosphine (TPP); diethyl azodicarboxylate (DEAD) / dioxane / 12 h / 20 °C

With sodium hydride; diisobutylaluminium hydride; triphenylphosphine; diethylazodicarboxylate; sodium methylate; In 1,4-dioxane; pyridine; methanol; diethylene glycol dimethyl ether; toluene; 1: Wittig-reaction / 2: Alcohol formation / 3: Acetylation / 4: Cycloaddition / 5: Deacetylation / 6: Substitution;
DOI:10.1016/S0040-4020(98)01067-9