Tetragastrin hydrochloride

Base Information

Chemical Name:Tetragastrin hydrochloride
CAS No.:5609-49-4
Molecular Formula:C29H36 N6 O6 S . Cl H
Molecular Weight:633.168
Hs Code.:
UNII:130LLV7CL9
Wikidata:Q27251454
Mol file:5609-49-4.mol

Synonyms:Tetragastrin hydrochloride;5609-49-4;Trp-Met-Asp-Phe hydrochloride;130LLV7CL9;UNII-130LLV7CL9;(3S)-3-[[(2S)-2-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid;hydrochloride;Alaninamide, L-tryptophyl-L-methionyl-L-aspartylphenyl-, hydrochloride;Alaninamide, L-tryptophyl-L-methionyl-L-aspartylphenyl-, monohydrochloride, L-;L-Phenylalaninamide, L-tryptophyl-L-methionyl-L-alpha-aspartyl-, monohydrochloride;Tetragastrin HCl;Trp-Met-Asp-Phe amide hydrochloride;AKOS040754167;Q27251454;L-PHENYLALANINAMIDE, L-TRYPTOPHYL-L-METHIONYL-L-.ALPHA.-ASPARTYL-, MONOHYDROCHLORIDE;(S)-4-((S)-1-amino-1-oxo-3-phenylpropan-2-ylamino)-3-((S)-2-((S)-2-amino-3-(1H-indol-3-yl)propanamido)-4-(methylthio)butanamido)-4-oxobutanoic acid hydrochloride

Suppliers and Price of Tetragastrin hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
TRP-MET-ASP-PHE AMIDE HYDROCHLORIDE 95.00%
5MG
$ 498.73

Alfa Aesar
Cholecystokinin, CCK Tetrapeptide (30-33)
1mg
$ 51.10

Total 8 raw suppliers

Chemical Property of Tetragastrin hydrochloride

Chemical Property:

Melting Point:220 °C(Solv: ethyl ether (60-29-7))
PSA：234.80000
LogP:3.82320
Storage Temp.:−20°C
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:16
Exact Mass:632.2183818
Heavy Atom Count:43
Complexity:948

Purity/Quality:

99% ^*data from raw suppliers

TRP-MET-ASP-PHE AMIDE HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CSCCC(C(=O)NC(CC(=O)O)C(=O)NC(CC1=CC=CC=C1)C(=O)N)NC(=O)C(CC2=CNC3=CC=CC=C32)N.Cl
Isomeric SMILES:CSCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)N.Cl

Technology Process of Tetragastrin hydrochloride

There total 9 articles about Tetragastrin hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 5549-50-8
Boc-Trp-Met-Asp(OBu^t)-Phe-NH₂

: 5609-49-4
L-Tryptophyl-L-methionyl-L-aspartyl-L-phenylalanine amide hydrochloride

Guidance literature:: With hydrogenchloride; acetic acid; ethanethiol; for 0.75h; Ambient temperature;

Reference yield: 92.0%

: 5235-21-2
N-tert-butoxycarbonyl-L-tryptophyl->L-methionyl->L-α-aspartyl->L-phenylalanine amide

: 5609-49-4
L-Tryptophyl-L-methionyl-L-aspartyl-L-phenylalanine amide hydrochloride

Guidance literature:: With hydrogenchloride; In acetic acid; at 20 ℃; for 1h;
DOI:10.1007/BF00757956

Reference yield:

: 5241-58-7
L-Phenylalanine amide

: 5609-49-4
L-Tryptophyl-L-methionyl-L-aspartyl-L-phenylalanine amide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) DMF, 15 min, -18 deg C; 2.) 2 h, -10 - -20 deg C; 4 h, room temperature

2: 84 percent / H₂ / Pd black / methanol / 12 h

3: 80 percent / HONB, DCCI / dimethylformamide / 1.) 2 h, -20 deg C; 2.) 3 h, room temperature

4: 98 percent / HCl, CH₃COOH, C₂H₅SH / 0.75 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; hydrogen; acetic acid; dicyclohexyl-carbodiimide; (3aR,4R,7S,7aS)-2-hydroxy-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione (N-hydroxy-5-exo-norbornene-2,3-dicarboximide); ethanethiol; isobutyl chloroformate; palladium; In methanol; N,N-dimethyl-formamide;