5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-ylamine maleate

Base Information

Chemical Name:5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-ylamine maleate
CAS No.:1353971-52-4
Molecular Formula:C₄H₄O₄*C₂₂H₁₄FN₅
Molecular Weight:483.458
Hs Code.:

Synonyms:5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-ylamine maleate

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Chemical Property of 5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-ylamine maleate

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Technology Process of 5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-ylamine maleate

There total 3 articles about 5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-ylamine maleate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1353967-37-9
5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-ylamine

: 110-16-7,26099-09-2
maleic acid

: 1353971-52-4
5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-ylamine maleate

Guidance literature:: In isopropyl alcohol; at 80 ℃; for 3h;

Reference yield:

: 80935-78-0
1-chloro-[2,6]naphthyridine

: 1353971-52-4
5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-ylamine maleate

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium bis(monoperoxyphthalate)hexahydrate / isopropyl alcohol / 40 h / 20 °C

2.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 16 h / 80 °C / Inert atmosphere

3.1: methanesulfonyl chloride; pyridine / 16 h / 0 - 20 °C

3.2: 16 h / 20 °C

4.1: isopropyl alcohol / 3 h / 80 °C

With pyridine; magnesium bis(monoperoxyphthalate)hexahydrate; sodium hydrogencarbonate; methanesulfonyl chloride; bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1353969-98-8
1-chloro-[2,6]naphthyridine 6-oxide

: 1353971-52-4
5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-ylamine maleate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 16 h / 80 °C / Inert atmosphere

2.1: methanesulfonyl chloride; pyridine / 16 h / 0 - 20 °C

2.2: 16 h / 20 °C

3.1: isopropyl alcohol / 3 h / 80 °C

With pyridine; sodium hydrogencarbonate; methanesulfonyl chloride; bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide; isopropyl alcohol;