N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucyl-L-proline allyl ester

Base Information

Chemical Name:N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucyl-L-proline allyl ester
CAS No.:236425-05-1
Molecular Formula:C₅₁H₈₂N₆O₁₀S
Molecular Weight:971.312
Hs Code.:

Synonyms:N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucyl-L-proline allyl ester

Suppliers and Price of N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucyl-L-proline allyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucyl-L-proline allyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucyl-L-proline allyl ester

There total 7 articles about N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucyl-L-proline allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 88224-07-1
proline allyl ester hydro-p-toluenesulfonate

: 236425-00-6
N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucine

: 236425-05-1
N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucyl-L-proline allyl ester

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; for 12h; Ambient temperature;
DOI:10.1016/S0968-0896(98)00251-X

Reference yield:

: 4530-20-5
BOC-glycine

: 236425-05-1
N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucyl-L-proline allyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / DIC, HOBt, Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

2: 1.) DTT, Et₃N, 2.) Et₃N / 1.) CH₂Cl₂, rt, 2 h, 2.) CH₂Cl₂, rt, 2 h

3: 89 percent / Pd(PPh₃)4, morpholine / tetrahydrofuran / 1 h / Ambient temperature

4: 78 percent / DIC, HOBt, Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

5: 87 percent / Pd(PPh₃)4, 1,3-dimethylbarbituric acid / tetrahydrofuran / 1 h / Ambient temperature

6: 83 percent / EDC, HOBt, Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; DL-dithiothreitol; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; dacarbazine; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0968-0896(98)00251-X

Reference yield:

: 207398-66-1
N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteine

: 236425-05-1
N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucyl-L-proline allyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / DIC, HOBt, Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

2: 87 percent / Pd(PPh₃)4, 1,3-dimethylbarbituric acid / tetrahydrofuran / 1 h / Ambient temperature

3: 83 percent / EDC, HOBt, Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; dacarbazine; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0968-0896(98)00251-X