N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucine

Base Information

Chemical Name:N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucine
CAS No.:236425-00-6
Molecular Formula:C₄₃H₇₁N₅O₉S
Molecular Weight:834.131
Hs Code.:

Synonyms:N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucine

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Chemical Property of N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucine

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Technology Process of N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucine

There total 6 articles about N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 236424-95-6
N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucine allyl ester

: 236425-00-6
N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; In tetrahydrofuran; for 1h; Ambient temperature;
DOI:10.1016/S0968-0896(98)00251-X

Reference yield:

: 4530-20-5
BOC-glycine

: 236425-00-6
N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucine

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / DIC, HOBt, Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

2: 1.) DTT, Et₃N, 2.) Et₃N / 1.) CH₂Cl₂, rt, 2 h, 2.) CH₂Cl₂, rt, 2 h

3: 89 percent / Pd(PPh₃)4, morpholine / tetrahydrofuran / 1 h / Ambient temperature

4: 78 percent / DIC, HOBt, Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

5: 87 percent / Pd(PPh₃)4, 1,3-dimethylbarbituric acid / tetrahydrofuran / 1 h / Ambient temperature

With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; DL-dithiothreitol; benzotriazol-1-ol; dacarbazine; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0968-0896(98)00251-X

Reference yield:

: 207398-66-1
N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteine

: 236425-00-6
N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucine

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / DIC, HOBt, Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

2: 87 percent / Pd(PPh₃)4, 1,3-dimethylbarbituric acid / tetrahydrofuran / 1 h / Ambient temperature

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; benzotriazol-1-ol; dacarbazine; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0968-0896(98)00251-X