3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)ethyl)-5-fluorobenzenesulfonic acid

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Chemical Name:3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)ethyl)-5-fluorobenzenesulfonic acid
CAS No.:1239957-32-4
Molecular Formula:C₂₇H₂₄Cl₂F₂N₂O₄S
Molecular Weight:581.467
Hs Code.:

Synonyms:3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)ethyl)-5-fluorobenzenesulfonic acid

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Chemical Property of 3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)ethyl)-5-fluorobenzenesulfonic acid

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Technology Process of 3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)ethyl)-5-fluorobenzenesulfonic acid

There total 11 articles about 3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)ethyl)-5-fluorobenzenesulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1239963-70-2
tert-butyl 3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)ethyl)-5-fluorophenylcarbamate

: 1239957-32-4
3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)ethyl)-5-fluorobenzenesulfonic acid

Guidance literature:: tert-butyl 3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)ethyl)-5-fluorophenylcarbamate; With trifluoroacetic acid; In dichloromethane; at 5 - 20 ℃; for 0.5h;

With hydrogenchloride; acetic acid; sodium nitrite; In water; at 4 - 6 ℃;

With sulfur dioxide; copper dichloride; In water; at 5 ℃;

Reference yield:

: C₂₇H₂₃Cl₃F₂N₂O₃S

: 1239957-32-4
3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)ethyl)-5-fluorobenzenesulfonic acid

Guidance literature:: C₂₇H₂₃Cl₃F₂N₂O₃S; With sodium hydroxide; In tetrahydrofuran; at 5 ℃; pH=8;

With hydrogenchloride; In water;

Reference yield:

: 350-28-7
3-fluoro-4-methyl-benzoic acid

: 1239957-32-4
3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)ethyl)-5-fluorobenzenesulfonic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: thionyl chloride / 0 - 60 °C

2.1: 4,4'-di-tert-butyl-2,2'-bipyridine / (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tetrahydrofuran / 80 °C / Inert atmosphere

3.1: copper dichloride / water; methanol / 90 °C

4.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 80 °C

5.1: toluene / 90 °C

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 50 °C

7.1: hydrogen / platinum(IV) oxide / ethanol / 3620.13 Torr

8.1: sodium hydroxide; water / methanol / 1 h

9.1: N-ethyl-N,N-diisopropylamine; diphenyl phosphoryl azide / toluene / 16 h / 0 - 80 °C

10.1: trifluoroacetic acid / dichloromethane / 0.5 h / 5 - 20 °C

10.2: 4 - 6 °C

10.3: 5 °C

With N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); diphenyl phosphoryl azide; water; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 4,4'-di-tert-butyl-2,2'-bipyridine; sodium hydroxide; copper dichloride; platinum(IV) oxide; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; dichloromethane; water; toluene; acetonitrile;