ethyl 3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)vinyl)-5-fluorobenzoate

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Chemical Name:ethyl 3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)vinyl)-5-fluorobenzoate
CAS No.:1239963-68-8
Molecular Formula:C₃₀H₂₆Cl₂F₂N₂O₃
Molecular Weight:571.451
Hs Code.:

Synonyms:ethyl 3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)vinyl)-5-fluorobenzoate

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Chemical Property of ethyl 3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)vinyl)-5-fluorobenzoate

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Technology Process of ethyl 3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)vinyl)-5-fluorobenzoate

There total 6 articles about ethyl 3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)vinyl)-5-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1239964-57-8
5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-carbaldehyde

: 1239963-67-7
(2-chloro-4-(ethoxycarbonyl)-6-fluorobenzyl)triphenylphosphonium bromide

: 1239963-68-8
ethyl 3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)vinyl)-5-fluorobenzoate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 50 ℃;

Reference yield:

: 350-28-7
3-fluoro-4-methyl-benzoic acid

: 1239963-68-8
ethyl 3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)vinyl)-5-fluorobenzoate

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / 0 - 60 °C

2: 4,4'-di-tert-butyl-2,2'-bipyridine / (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tetrahydrofuran / 80 °C / Inert atmosphere

3: copper dichloride / water; methanol / 90 °C

4: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 80 °C

5: toluene / 90 °C

6: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 50 °C

With N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); 1,8-diazabicyclo[5.4.0]undec-7-ene; 4,4'-di-tert-butyl-2,2'-bipyridine; copper dichloride; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; In tetrahydrofuran; methanol; tetrachloromethane; water; toluene; acetonitrile;

Reference yield:

: 1239964-19-2
ethyl 3-fluoro-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

: 1239963-68-8
ethyl 3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)vinyl)-5-fluorobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: copper dichloride / water; methanol / 90 °C

2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 80 °C

3: toluene / 90 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 50 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); 1,8-diazabicyclo[5.4.0]undec-7-ene; copper dichloride; In methanol; tetrachloromethane; water; toluene; acetonitrile;