tert-butyl 3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)ethyl)-5-fluorophenylcarbamate

Base Information

Chemical Name:tert-butyl 3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)ethyl)-5-fluorophenylcarbamate
CAS No.:1239963-70-2
Molecular Formula:C₃₂H₃₃Cl₂F₂N₃O₃
Molecular Weight:616.535
Hs Code.:

Synonyms:tert-butyl 3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)ethyl)-5-fluorophenylcarbamate

Suppliers and Price of tert-butyl 3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)ethyl)-5-fluorophenylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl 3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)ethyl)-5-fluorophenylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)ethyl)-5-fluorophenylcarbamate

There total 9 articles about tert-butyl 3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)ethyl)-5-fluorophenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1239957-31-3
3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)ethyl)-5-fluorobenzoic acid

: 75-65-0
tert-butyl alcohol

: 1239963-70-2
tert-butyl 3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)ethyl)-5-fluorophenylcarbamate

Guidance literature:: With diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine; In toluene; at 0 - 80 ℃; for 16h;

Reference yield:

: 350-28-7
3-fluoro-4-methyl-benzoic acid

: 1239963-70-2
tert-butyl 3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)ethyl)-5-fluorophenylcarbamate

Guidance literature:: Multi-step reaction with 9 steps

1: thionyl chloride / 0 - 60 °C

2: 4,4'-di-tert-butyl-2,2'-bipyridine / (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tetrahydrofuran / 80 °C / Inert atmosphere

3: copper dichloride / water; methanol / 90 °C

4: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 80 °C

5: toluene / 90 °C

6: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 50 °C

7: hydrogen / platinum(IV) oxide / ethanol / 3620.13 Torr

8: sodium hydroxide; water / methanol / 1 h

9: N-ethyl-N,N-diisopropylamine; diphenyl phosphoryl azide / toluene / 16 h / 0 - 80 °C

With N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); diphenyl phosphoryl azide; water; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; 4,4'-di-tert-butyl-2,2'-bipyridine; sodium hydroxide; copper dichloride; platinum(IV) oxide; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; water; toluene; acetonitrile;

Reference yield:

: 1239964-21-6
ethyl 4-(bromomethyl)-3-chloro-5-fluorobenzoate

: 1239963-70-2
tert-butyl 3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)ethyl)-5-fluorophenylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / 90 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 50 °C

3: hydrogen / platinum(IV) oxide / ethanol / 3620.13 Torr

4: sodium hydroxide; water / methanol / 1 h

5: N-ethyl-N,N-diisopropylamine; diphenyl phosphoryl azide / toluene / 16 h / 0 - 80 °C

With diphenyl phosphoryl azide; water; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; sodium hydroxide; platinum(IV) oxide; In methanol; ethanol; toluene; acetonitrile;