ethyl 2-(diphenylmethyleneamino)-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)butanoate

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Chemical Name:ethyl 2-(diphenylmethyleneamino)-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)butanoate
CAS No.:1307813-12-2
Molecular Formula:C₄₁H₃₅F₃N₄O₃
Molecular Weight:688.749
Hs Code.:

Synonyms:ethyl 2-(diphenylmethyleneamino)-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)butanoate

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Chemical Property of ethyl 2-(diphenylmethyleneamino)-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)butanoate

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Technology Process of ethyl 2-(diphenylmethyleneamino)-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)butanoate

There total 6 articles about ethyl 2-(diphenylmethyleneamino)-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1307813-11-1
ethyl 2-(diphenylmethyleneamino)-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)butanoate

: 74-88-4
methyl iodide

: 1307813-12-2
ethyl 2-(diphenylmethyleneamino)-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)butanoate

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 3470-50-6
6-Hydroxy-1-tetralone

: 1307813-12-2
ethyl 2-(diphenylmethyleneamino)-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)butanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / 4 h / 0 - 20 °C

2.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 14 h / 100 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; sodium acetate / methanol / 1.5 h / 80 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

4.2: 1.48 h / 0 °C / Cooling with ice

4.3: 0.5 h / 20 - 100 °C / Inert atmosphere

5.1: caesium carbonate / dimethyl sulfoxide / 0.5 h / 20 °C / Inert atmosphere

5.2: 5 h / 40 °C / Inert atmosphere

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

With pyridine; hydroxylamine hydrochloride; sodium acetate; caesium carbonate; lithium chloride; lithium hexamethyldisilazane; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dimethyl sulfoxide;

Reference yield:

: 144464-64-2
5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate

: 1307813-12-2
ethyl 2-(diphenylmethyleneamino)-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)butanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 14 h / 100 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride; sodium acetate / methanol / 1.5 h / 80 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3.2: 1.48 h / 0 °C / Cooling with ice

3.3: 0.5 h / 20 - 100 °C / Inert atmosphere

4.1: caesium carbonate / dimethyl sulfoxide / 0.5 h / 20 °C / Inert atmosphere

4.2: 5 h / 40 °C / Inert atmosphere

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

With hydroxylamine hydrochloride; sodium acetate; caesium carbonate; lithium chloride; lithium hexamethyldisilazane; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dimethyl sulfoxide;