3-(6-(1-methyl-1H-pyrazol-4-yl)-5-nitro-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide

Base Information

Chemical Name:3-(6-(1-methyl-1H-pyrazol-4-yl)-5-nitro-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide
CAS No.:1351813-08-5
Molecular Formula:C₂₃H₂₈N₆O₅SSi
Molecular Weight:528.664
Hs Code.:

Synonyms:3-(6-(1-methyl-1H-pyrazol-4-yl)-5-nitro-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide

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Chemical Property of 3-(6-(1-methyl-1H-pyrazol-4-yl)-5-nitro-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide

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Technology Process of 3-(6-(1-methyl-1H-pyrazol-4-yl)-5-nitro-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide

There total 7 articles about 3-(6-(1-methyl-1H-pyrazol-4-yl)-5-nitro-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1351813-06-3
3-iodo-6-(1-methyl-1H-pyrazol-4-yl)-5-nitro-1H-indazole

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 850568-74-0
3-(dihydroxyboranyl)benzene-1-sulfonamide

: 1351813-08-5
3-(6-(1-methyl-1H-pyrazol-4-yl)-5-nitro-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide

Guidance literature:: 3-iodo-6-(1-methyl-1H-pyrazol-4-yl)-5-nitro-1H-indazole; (2-trimethylethylsilylethoxy)methyl chloride; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.666667h;

3-(dihydroxyboranyl)benzene-1-sulfonamide; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In tetrahydrofuran; water; for 3h; Inert atmosphere; Reflux;
DOI:10.1021/jm4000215

Reference yield:

: 1351813-04-1
C₁₇H₂₃N₅O₃Si

: 1351813-08-5
3-(6-(1-methyl-1H-pyrazol-4-yl)-5-nitro-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutyl ammonium fluoride; ethylenediamine / tetrahydrofuran / 8 h / Reflux

2.1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.67 h / 0 - 20 °C

3.2: 3 h / Inert atmosphere; Reflux

With tetrabutyl ammonium fluoride; iodine; sodium hydride; ethylenediamine; potassium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: |Suzuki Coupling / 3.2: |Suzuki Coupling;
DOI:10.1021/jm4000215

Reference yield:

: 1351813-03-0
C₁₃H₁₈BrN₃O₃Si

: 1351813-08-5
3-(6-(1-methyl-1H-pyrazol-4-yl)-5-nitro-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium carbonate / tetrahydrofuran; water / 3.5 h / Reflux; Inert atmosphere

2.1: tetrabutyl ammonium fluoride; ethylenediamine / tetrahydrofuran / 8 h / Reflux

3.1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 2 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.67 h / 0 - 20 °C

4.2: 3 h / Inert atmosphere; Reflux

With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); tetrabutyl ammonium fluoride; iodine; sodium hydride; potassium carbonate; ethylenediamine; potassium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; 1.1: |Suzuki Coupling / 2.1: |Suzuki Coupling / 4.2: |Suzuki Coupling;
DOI:10.1021/jm4000215