Technology Process of 3-(6-(1-methyl-1H-pyrazol-4-yl)-5-nitro-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide
There total 7 articles about 3-(6-(1-methyl-1H-pyrazol-4-yl)-5-nitro-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-iodo-6-(1-methyl-1H-pyrazol-4-yl)-5-nitro-1H-indazole; (2-trimethylethylsilylethoxy)methyl chloride;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 0.666667h;
3-(dihydroxyboranyl)benzene-1-sulfonamide;
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate;
In
tetrahydrofuran; water;
for 3h;
Inert atmosphere;
Reflux;
DOI:10.1021/jm4000215
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrabutyl ammonium fluoride; ethylenediamine / tetrahydrofuran / 8 h / Reflux
2.1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 2 h / 20 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 0.67 h / 0 - 20 °C
3.2: 3 h / Inert atmosphere; Reflux
With
tetrabutyl ammonium fluoride; iodine; sodium hydride; ethylenediamine; potassium hydroxide;
In
tetrahydrofuran; N,N-dimethyl-formamide;
1.1: |Suzuki Coupling / 3.2: |Suzuki Coupling;
DOI:10.1021/jm4000215
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium carbonate / tetrahydrofuran; water / 3.5 h / Reflux; Inert atmosphere
2.1: tetrabutyl ammonium fluoride; ethylenediamine / tetrahydrofuran / 8 h / Reflux
3.1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 2 h / 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide / 0.67 h / 0 - 20 °C
4.2: 3 h / Inert atmosphere; Reflux
With
dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); tetrabutyl ammonium fluoride; iodine; sodium hydride; potassium carbonate; ethylenediamine; potassium hydroxide;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
1.1: |Suzuki Coupling / 2.1: |Suzuki Coupling / 4.2: |Suzuki Coupling;
DOI:10.1021/jm4000215
