(3S,4R)-6,7-dimethoxy-1-methyl-3-phenyl-4-(tert-butyldiphenylsilyloxy)-3,4-dihydroisoquinoline

Base Information

Chemical Name:(3S*,4R*)-6,7-dimethoxy-1-methyl-3-phenyl-4-(tert-butyldiphenylsilyloxy)-3,4-dihydroisoquinoline
CAS No.:143378-41-0
Molecular Formula:C₃₄H₃₇NO₃Si
Molecular Weight:535.758
Hs Code.:

Synonyms:(3S*,4R*)-6,7-dimethoxy-1-methyl-3-phenyl-4-(tert-butyldiphenylsilyloxy)-3,4-dihydroisoquinoline

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Chemical Property of (3S*,4R*)-6,7-dimethoxy-1-methyl-3-phenyl-4-(tert-butyldiphenylsilyloxy)-3,4-dihydroisoquinoline

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Technology Process of (3S*,4R*)-6,7-dimethoxy-1-methyl-3-phenyl-4-(tert-butyldiphenylsilyloxy)-3,4-dihydroisoquinoline

There total 6 articles about (3S*,4R*)-6,7-dimethoxy-1-methyl-3-phenyl-4-(tert-butyldiphenylsilyloxy)-3,4-dihydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 143378-39-6
N-<2-(3,4-dimethoxyphenyl)-1-phenyl-2-(tert-butyldiphenylsilyloxy)ethyl>acetamide

: 143378-41-0
(3S*,4R*)-6,7-dimethoxy-1-methyl-3-phenyl-4-(tert-butyldiphenylsilyloxy)-3,4-dihydroisoquinoline

Guidance literature:: With phosphorus pentachloride; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1016/S0040-4020(01)80450-6

Reference yield:

: 6309-18-8
2-(3,4-dimethoxyphenyl)-2-hydroxyacetonitrile

: 143378-41-0
(3S*,4R*)-6,7-dimethoxy-1-methyl-3-phenyl-4-(tert-butyldiphenylsilyloxy)-3,4-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / dimethylformamide / 1.5 h

2: 2) NaBH₄ / 1) ether, 6 h, reflux, 2) MeOH, overnight

3: 95 percent / DMAP, Et₃N / CH₂Cl₂ / Ambient temperature

4: 88 percent / PCl₅ / CH₂Cl₂ / 1 h / Ambient temperature

With 1H-imidazole; dmap; sodium tetrahydroborate; phosphorus pentachloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)80450-6

Reference yield:

: phenylmagnesium bromide

: 143378-41-0
(3S*,4R*)-6,7-dimethoxy-1-methyl-3-phenyl-4-(tert-butyldiphenylsilyloxy)-3,4-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 2) NaBH₄ / 1) ether, 6 h, reflux, 2) MeOH, overnight

2: 95 percent / DMAP, Et₃N / CH₂Cl₂ / Ambient temperature

3: 88 percent / PCl₅ / CH₂Cl₂ / 1 h / Ambient temperature

With dmap; sodium tetrahydroborate; phosphorus pentachloride; triethylamine; In dichloromethane;
DOI:10.1016/S0040-4020(01)80450-6