5,5-dimethyl-6-methylene-2-p-tolylamino-5,6-dihydro-4H-thiopyran-3-carbaldehyde

Base Information

Chemical Name:5,5-dimethyl-6-methylene-2-p-tolylamino-5,6-dihydro-4H-thiopyran-3-carbaldehyde
CAS No.:1307292-87-0
Molecular Formula:C₁₆H₁₉NOS
Molecular Weight:273.399
Hs Code.:

Synonyms:5,5-dimethyl-6-methylene-2-p-tolylamino-5,6-dihydro-4H-thiopyran-3-carbaldehyde

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Chemical Property of 5,5-dimethyl-6-methylene-2-p-tolylamino-5,6-dihydro-4H-thiopyran-3-carbaldehyde

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Technology Process of 5,5-dimethyl-6-methylene-2-p-tolylamino-5,6-dihydro-4H-thiopyran-3-carbaldehyde

There total 5 articles about 5,5-dimethyl-6-methylene-2-p-tolylamino-5,6-dihydro-4H-thiopyran-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1307292-86-9
[5,5-dimethyl-6-methylene-tetrahydro-thiopyran-2-ylidene]-p-tolyl-amine

: 109-94-4
formic acid ethyl ester

: 1307292-87-0
5,5-dimethyl-6-methylene-2-p-tolylamino-5,6-dihydro-4H-thiopyran-3-carbaldehyde

Guidance literature:: [5,5-dimethyl-6-methylene-tetrahydro-thiopyran-2-ylidene]-p-tolyl-amine; With lithium diisopropyl amide; In tetrahydrofuran; cyclohexane; at -78 ℃; for 0.5h; Inert atmosphere;

formic acid ethyl ester; In tetrahydrofuran; cyclohexane; at 20 ℃; for 1h;

Reference yield:

: 53589-56-3
3,3-dimethyl-4-pentenol

: 1307292-87-0
5,5-dimethyl-6-methylene-2-p-tolylamino-5,6-dihydro-4H-thiopyran-3-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C

2.1: lithium bromide / tetrahydrofuran / 2 h / Reflux

3.1: magnesium / iodine / tetrahydrofuran / 1 h / Reflux

3.2: 1 h / 0 - 20 °C

4.1: iodine / tetrahydrofuran / 0 - 20 °C

4.2: 0 °C

5.1: lithium diisopropyl amide / cyclohexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

5.2: 1 h / 20 °C

With iodine; magnesium; triethylamine; lithium bromide; lithium diisopropyl amide; iodine; In tetrahydrofuran; cyclohexane;

Reference yield:

: 70472-96-7
5-bromo-3,3-dimethyl-pent-1-ene

: 1307292-87-0
5,5-dimethyl-6-methylene-2-p-tolylamino-5,6-dihydro-4H-thiopyran-3-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium / iodine / tetrahydrofuran / 1 h / Reflux

1.2: 1 h / 0 - 20 °C

2.1: iodine / tetrahydrofuran / 0 - 20 °C

2.2: 0 °C

3.1: lithium diisopropyl amide / cyclohexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: 1 h / 20 °C

With iodine; magnesium; lithium diisopropyl amide; iodine; In tetrahydrofuran; cyclohexane;