tert-butyl ethyl(4-(5-(thiophene-2-carboximidamido)-1H-indol-3-yl)cyclohex-3-enyl)carbamate

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Chemical Name:tert-butyl ethyl(4-(5-(thiophene-2-carboximidamido)-1H-indol-3-yl)cyclohex-3-enyl)carbamate
CAS No.:1152478-60-8
Molecular Formula:C₂₆H₃₂N₄O₂S
Molecular Weight:464.632
Hs Code.:

Synonyms:tert-butyl ethyl(4-(5-(thiophene-2-carboximidamido)-1H-indol-3-yl)cyclohex-3-enyl)carbamate

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Chemical Property of tert-butyl ethyl(4-(5-(thiophene-2-carboximidamido)-1H-indol-3-yl)cyclohex-3-enyl)carbamate

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Technology Process of tert-butyl ethyl(4-(5-(thiophene-2-carboximidamido)-1H-indol-3-yl)cyclohex-3-enyl)carbamate

There total 7 articles about tert-butyl ethyl(4-(5-(thiophene-2-carboximidamido)-1H-indol-3-yl)cyclohex-3-enyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 915037-68-2
tert-butyl 4-(5-amino-1H-indol-3-yl)cyclohex-3-enyl(ethyl)carbamate

: methyl thiophene-2-carbimidothioate hydroiodide

: 1152478-60-8
tert-butyl ethyl(4-(5-(thiophene-2-carboximidamido)-1H-indol-3-yl)cyclohex-3-enyl)carbamate

Guidance literature:: tert-butyl 4-(5-amino-1H-indol-3-yl)cyclohex-3-enyl(ethyl)carbamate; methyl thiophene-2-carbimidothioate hydroiodide; In ethanol; at 20 ℃; for 24h;

With sodium hydrogencarbonate; In water;

Reference yield: 85.0%

: 168897-51-6
methyl thiophene-2-carboximidothioate

: 915037-68-2
tert-butyl 4-(5-amino-1H-indol-3-yl)cyclohex-3-enyl(ethyl)carbamate

: 1152478-60-8
tert-butyl ethyl(4-(5-(thiophene-2-carboximidamido)-1H-indol-3-yl)cyclohex-3-enyl)carbamate

Guidance literature:: In ethanol; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/jm300138g

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1152478-60-8
tert-butyl ethyl(4-(5-(thiophene-2-carboximidamido)-1H-indol-3-yl)cyclohex-3-enyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / methanol / 0.17 h / 20 °C / Inert atmosphere

1.2: 36 h / Inert atmosphere; Reflux

2.1: hydrogenchloride / water; acetone / 14 h / 20 °C / Inert atmosphere

3.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 14 h / 20 °C / Inert atmosphere

4.1: triethylamine / 1,4-dioxane / 14 h / 20 °C / Inert atmosphere

5.1: hydrazine hydrate / methanol / 0.08 h / Inert atmosphere; Reflux

6.1: ethanol / 24 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium tris(acetoxy)borohydride; hydrazine hydrate; acetic acid; triethylamine; potassium hydroxide; In 1,4-dioxane; methanol; ethanol; water; 1,2-dichloro-ethane; acetone;
DOI:10.1021/jm300138g