N-(3-(4-(ethylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide

Base Information

Chemical Name:N-(3-(4-(ethylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide
CAS No.:1152478-57-3
Molecular Formula:C₂₁H₂₄N₄S
Molecular Weight:364.514
Hs Code.:

Synonyms:N-(3-(4-(ethylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide

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Chemical Property of N-(3-(4-(ethylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide

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Technology Process of N-(3-(4-(ethylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide

There total 8 articles about N-(3-(4-(ethylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1152478-60-8
tert-butyl ethyl(4-(5-(thiophene-2-carboximidamido)-1H-indol-3-yl)cyclohex-3-enyl)carbamate

: 1152478-57-3
N-(3-(4-(ethylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm300138g

Reference yield:

: 915037-67-1
tert-butyl ethyl(4-(5-nitro-1H-indol-3-yl)cyclohex-3-enyl)carbamate

: 1152478-57-3
N-(3-(4-(ethylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / methanol / 0.08 h / Inert atmosphere; Reflux

2: ethanol / 24 h / 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 2 h / 0 °C / Inert atmosphere

With hydrazine hydrate; trifluoroacetic acid; In methanol; ethanol; dichloromethane;
DOI:10.1021/jm300138g

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1152478-57-3
N-(3-(4-(ethylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydroxide / methanol / 0.17 h / 20 °C / Inert atmosphere

1.2: 36 h / Inert atmosphere; Reflux

2.1: hydrogenchloride / water; acetone / 14 h / 20 °C / Inert atmosphere

3.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 14 h / 20 °C / Inert atmosphere

4.1: triethylamine / 1,4-dioxane / 14 h / 20 °C / Inert atmosphere

5.1: hydrazine hydrate / methanol / 0.08 h / Inert atmosphere; Reflux

6.1: ethanol / 24 h / 20 °C / Inert atmosphere

7.1: trifluoroacetic acid / dichloromethane / 2 h / 0 °C / Inert atmosphere

With hydrogenchloride; sodium tris(acetoxy)borohydride; hydrazine hydrate; acetic acid; triethylamine; trifluoroacetic acid; potassium hydroxide; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; acetone;
DOI:10.1021/jm300138g