3-{3-(3,4-dimethoxybenzyl)-2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazol-4-yl}-acrylic acid ethyl ester

Base Information

Chemical Name:3-{3-(3,4-dimethoxybenzyl)-2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazol-4-yl}-acrylic acid ethyl ester
CAS No.:852615-26-0
Molecular Formula:C₂₆H₃₀N₂O₇S
Molecular Weight:514.599
Hs Code.:

Synonyms:3-{3-(3,4-dimethoxybenzyl)-2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazol-4-yl}-acrylic acid ethyl ester

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Chemical Property of 3-{3-(3,4-dimethoxybenzyl)-2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazol-4-yl}-acrylic acid ethyl ester

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Technology Process of 3-{3-(3,4-dimethoxybenzyl)-2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazol-4-yl}-acrylic acid ethyl ester

There total 11 articles about 3-{3-(3,4-dimethoxybenzyl)-2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazol-4-yl}-acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852615-25-9
3-(3,4-dimethoxybenzyl)-2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazole-4-carbaldehyde

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 852615-26-0
3-{3-(3,4-dimethoxybenzyl)-2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazol-4-yl}-acrylic acid ethyl ester

Guidance literature:: diethoxyphosphoryl-acetic acid ethyl ester; With sodium hydride; In tetrahydrofuran; at 25 ℃; for 0.666667h;

3-(3,4-dimethoxybenzyl)-2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazole-4-carbaldehyde; In tetrahydrofuran; for 2h;
DOI:10.1021/ol0473602

Reference yield:

: 852615-22-6
2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazole-4-carboxylic acid methyl ester

: 852615-26-0
3-{3-(3,4-dimethoxybenzyl)-2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazol-4-yl}-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 100 percent / K₂CO₃ / dimethylformamide / 65 °C

2.1: DIBAl-H / CH₂Cl₂ / -78 °C

3.1: activated manganese dioxide / CH₂Cl₂

4.1: NaH / tetrahydrofuran / 0 - 25 °C

4.2: tetrahydrofuran / 2 h

With manganese(IV) oxide; sodium hydride; diisobutylaluminium hydride; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 4.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/j.tet.2005.12.068

Reference yield:

: 7306-46-9
4-chloromethyl-1,2-dimethoxy-benzene

: 852615-26-0
3-{3-(3,4-dimethoxybenzyl)-2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazol-4-yl}-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 100 percent / K₂CO₃ / dimethylformamide / 65 °C

2.1: DIBAl-H / CH₂Cl₂ / -78 °C

3.1: activated manganese dioxide / CH₂Cl₂

4.1: NaH / tetrahydrofuran / 0 - 25 °C

4.2: tetrahydrofuran / 2 h

With manganese(IV) oxide; sodium hydride; diisobutylaluminium hydride; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 4.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/j.tet.2005.12.068