N-<<1-<3-(4-acetyl-2-methoxyphenoxy)propyl>-4-piperidinyl>bis(4-fluorophenyl)methyl>acetamide

Base Information

Chemical Name:N-<<1-<3-(4-acetyl-2-methoxyphenoxy)propyl>-4-piperidinyl>bis(4-fluorophenyl)methyl>acetamide
CAS No.:135257-04-4
Molecular Formula:C₃₂H₃₆F₂N₂O₄
Molecular Weight:550.646
Hs Code.:

Synonyms:N-<<1-<3-(4-acetyl-2-methoxyphenoxy)propyl>-4-piperidinyl>bis(4-fluorophenyl)methyl>acetamide

Suppliers and Price of N-<<1-<3-(4-acetyl-2-methoxyphenoxy)propyl>-4-piperidinyl>bis(4-fluorophenyl)methyl>acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<<1-<3-(4-acetyl-2-methoxyphenoxy)propyl>-4-piperidinyl>bis(4-fluorophenyl)methyl>acetamide

Chemical Property:

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Technology Process of N-<<1-<3-(4-acetyl-2-methoxyphenoxy)propyl>-4-piperidinyl>bis(4-fluorophenyl)methyl>acetamide

There total 6 articles about N-<<1-<3-(4-acetyl-2-methoxyphenoxy)propyl>-4-piperidinyl>bis(4-fluorophenyl)methyl>acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 135257-02-2
1-[4-(3-{4-[Amino-bis-(4-fluoro-phenyl)-methyl]-piperidin-1-yl}-propoxy)-3-methoxy-phenyl]-ethanone

: 75-36-5
acetyl chloride

: 135257-04-4
N-<<1-<3-(4-acetyl-2-methoxyphenoxy)propyl>-4-piperidinyl>bis(4-fluorophenyl)methyl>acetamide

Guidance literature:: With potassium carbonate; In acetonitrile; Ambient temperature;
DOI:10.1021/jm00114a009

Reference yield:

: 58113-30-7
4-(3-chloropropoxy)-3-methoxyacetophenone

: 135257-04-4
N-<<1-<3-(4-acetyl-2-methoxyphenoxy)propyl>-4-piperidinyl>bis(4-fluorophenyl)methyl>acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃, KI / butan-1-ol / Heating

2: 43 percent / K₂CO₃ / acetonitrile / Ambient temperature

With potassium carbonate; potassium iodide; In acetonitrile; butan-1-ol;
DOI:10.1021/jm00114a009

Reference yield:

: 135256-88-1
4-<2-amino-1,1-bis(4-fluorophenyl)-2-oxoethyl>-1-piperidinecarboxylic acid methyl ester

: 135257-04-4
N-<<1-<3-(4-acetyl-2-methoxyphenoxy)propyl>-4-piperidinyl>bis(4-fluorophenyl)methyl>acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 50percent aq. NaOH, Br₂ / 16 h / Ambient temperature

2: 50percent aq. NaOH / methanol / 16 h / Heating

3: K₂CO₃, KI / butan-1-ol / Heating

4: 43 percent / K₂CO₃ / acetonitrile / Ambient temperature

With sodium hydroxide; bromine; potassium carbonate; potassium iodide; In methanol; acetonitrile; butan-1-ol;
DOI:10.1021/jm00114a009