tert-butyl N-[1-(4-phenoxyphenoxy)-3-(2H-tetrazol-2-yl)propan-2-yl]carbamate

Base Information

Chemical Name:tert-butyl N-[1-(4-phenoxyphenoxy)-3-(2H-tetrazol-2-yl)propan-2-yl]carbamate
CAS No.:1610891-32-1
Molecular Formula:C₂₁H₂₅N₅O₄
Molecular Weight:411.461
Hs Code.:

Synonyms:tert-butyl N-[1-(4-phenoxyphenoxy)-3-(2H-tetrazol-2-yl)propan-2-yl]carbamate

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Chemical Property of tert-butyl N-[1-(4-phenoxyphenoxy)-3-(2H-tetrazol-2-yl)propan-2-yl]carbamate

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Technology Process of tert-butyl N-[1-(4-phenoxyphenoxy)-3-(2H-tetrazol-2-yl)propan-2-yl]carbamate

There total 4 articles about tert-butyl N-[1-(4-phenoxyphenoxy)-3-(2H-tetrazol-2-yl)propan-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 288-94-8
1H-tetrazole

: 1610891-27-4
tert-butyl 2-[(4-phenoxyphenoxy)methyl]aziridine-1-carboxylate

: 1610891-32-1
tert-butyl N-[1-(4-phenoxyphenoxy)-3-(2H-tetrazol-2-yl)propan-2-yl]carbamate

: 1610891-33-2
tert-butyl N-[1-(4-phenoxyphenoxy)-3-(1H-tetrazol-1-yl)propan-2-yl]carbamate

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; acetonitrile; at 20 ℃; for 3h;
DOI:10.1080/00397911.2013.868490

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1610891-32-1
tert-butyl N-[1-(4-phenoxyphenoxy)-3-(2H-tetrazol-2-yl)propan-2-yl]carbamate

: 1610891-33-2
tert-butyl N-[1-(4-phenoxyphenoxy)-3-(1H-tetrazol-1-yl)propan-2-yl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / diethyl ether / 2 h / 0 °C

2: triethylamine; dmap / dichloromethane / 12 h / 20 °C

3: tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide / dichloromethane / 12 h / 20 °C

4: boron trifluoride diethyl etherate / acetonitrile; dichloromethane / 3 h / 20 °C

With dmap; boron trifluoride diethyl etherate; tetra(n-butyl)ammonium hydrogensulfate; triethylamine; potassium hydroxide; In diethyl ether; dichloromethane; acetonitrile;
DOI:10.1080/00397911.2013.868490

Reference yield:

: 1610891-25-2
tert-butyl N-[2-hydroxy-3-(4-phenoxyphenoxy)propyl]carbamate

: 1610891-32-1
tert-butyl N-[1-(4-phenoxyphenoxy)-3-(2H-tetrazol-2-yl)propan-2-yl]carbamate

: 1610891-33-2
tert-butyl N-[1-(4-phenoxyphenoxy)-3-(1H-tetrazol-1-yl)propan-2-yl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; dmap / dichloromethane / 12 h / 20 °C

2: tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide / dichloromethane / 12 h / 20 °C

3: boron trifluoride diethyl etherate / acetonitrile; dichloromethane / 3 h / 20 °C

With dmap; boron trifluoride diethyl etherate; tetra(n-butyl)ammonium hydrogensulfate; triethylamine; potassium hydroxide; In dichloromethane; acetonitrile;
DOI:10.1080/00397911.2013.868490