1-(4-phenoxyphenoxy)-3-(2H-tetrazol-2-yl)propan-2-amine hydrochloride

Base Information

Chemical Name:1-(4-phenoxyphenoxy)-3-(2H-tetrazol-2-yl)propan-2-amine hydrochloride
CAS No.:1610891-34-3
Molecular Formula:C₁₆H₁₇N₅O₂*ClH
Molecular Weight:347.804
Hs Code.:

Synonyms:1-(4-phenoxyphenoxy)-3-(2H-tetrazol-2-yl)propan-2-amine hydrochloride

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Chemical Property of 1-(4-phenoxyphenoxy)-3-(2H-tetrazol-2-yl)propan-2-amine hydrochloride

Chemical Property:

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Technology Process of 1-(4-phenoxyphenoxy)-3-(2H-tetrazol-2-yl)propan-2-amine hydrochloride

There total 3 articles about 1-(4-phenoxyphenoxy)-3-(2H-tetrazol-2-yl)propan-2-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1610891-32-1
tert-butyl N-[1-(4-phenoxyphenoxy)-3-(2H-tetrazol-2-yl)propan-2-yl]carbamate

: 1610891-34-3
1-(4-phenoxyphenoxy)-3-(2H-tetrazol-2-yl)propan-2-amine hydrochloride

Guidance literature:: tert-butyl N-[1-(4-phenoxyphenoxy)-3-(2H-tetrazol-2-yl)propan-2-yl]carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With hydrogenchloride; In diethyl ether; dichloromethane;
DOI:10.1080/00397911.2013.868490

Reference yield:

: 1610891-25-2
tert-butyl N-[2-hydroxy-3-(4-phenoxyphenoxy)propyl]carbamate

: 1610891-34-3
1-(4-phenoxyphenoxy)-3-(2H-tetrazol-2-yl)propan-2-amine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; dmap / dichloromethane / 12 h / 20 °C

2: tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide / dichloromethane / 12 h / 20 °C

3: boron trifluoride diethyl etherate / acetonitrile; dichloromethane / 3 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With dmap; boron trifluoride diethyl etherate; tetra(n-butyl)ammonium hydrogensulfate; triethylamine; trifluoroacetic acid; potassium hydroxide; In dichloromethane; acetonitrile;
DOI:10.1080/00397911.2013.868490

Reference yield:

: 1610891-26-3
1-[(tert-butoxycarbonyl)amino]-3-(4-phenoxyphenoxy)propan-2-yl 4-methylbenzenesulfonate

: 1610891-34-3
1-(4-phenoxyphenoxy)-3-(2H-tetrazol-2-yl)propan-2-amine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide / dichloromethane / 12 h / 20 °C

2: boron trifluoride diethyl etherate / acetonitrile; dichloromethane / 3 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With boron trifluoride diethyl etherate; tetra(n-butyl)ammonium hydrogensulfate; trifluoroacetic acid; potassium hydroxide; In dichloromethane; acetonitrile;
DOI:10.1080/00397911.2013.868490