5-cyclopropyl-6-(4-fluorophenyl)-3-methyl-1-phenyl-4-thiophen-2-yl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine

Base Information

• Chemical Name: 5-cyclopropyl-6-(4-fluorophenyl)-3-methyl-1-phenyl-4-thiophen-2-yl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine
• CAS No.: 1570369-81-1
• Molecular Formula: C₂₅H₂₁FN₄S
• Molecular Weight: 428.533

Synonyms:5-cyclopropyl-6-(4-fluorophenyl)-3-methyl-1-phenyl-4-thiophen-2-yl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine

Chemical Property of 5-cyclopropyl-6-(4-fluorophenyl)-3-methyl-1-phenyl-4-thiophen-2-yl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine

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Technology Process of 5-cyclopropyl-6-(4-fluorophenyl)-3-methyl-1-phenyl-4-thiophen-2-yl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine

There total 3 articles about 5-cyclopropyl-6-(4-fluorophenyl)-3-methyl-1-phenyl-4-thiophen-2-yl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

thiophene-2-carbaldehyde (98-03-3) + N'-cyclopropyl-4-fluoro-N-(5-methyl-2-phenyl-2H-pyrazol-3-yl)benzamidine (1006463-59-7) → 5-cyclopropyl-6-(4-fluorophenyl)-3-methyl-1-phenyl-4-thiophen-2-yl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine (1570369-81-1)

Guidance literature:

With chloro-trimethyl-silane; In N,N-dimethyl-formamide; at 100 ℃; Sealed tube;

DOI:10.1055/s-0033-1340158

Reference yield:

1-Phenyl-3-methyl-5-aminopyrazole (1131-18-6) → 5-cyclopropyl-6-(4-fluorophenyl)-3-methyl-1-phenyl-4-thiophen-2-yl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine (1570369-81-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 5 h / 0 - 40 °C

2: chloro-trimethyl-silane / N,N-dimethyl-formamide / 100 °C / Sealed tube

With chloro-trimethyl-silane; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1055/s-0033-1340158

Reference yield:

N-(cyclopropyl)-4-fluorobenzimidoyl chloride (1192139-71-1) → 5-cyclopropyl-6-(4-fluorophenyl)-3-methyl-1-phenyl-4-thiophen-2-yl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine (1570369-81-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 5 h / 0 - 40 °C

2: chloro-trimethyl-silane / N,N-dimethyl-formamide / 100 °C / Sealed tube

With chloro-trimethyl-silane; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1055/s-0033-1340158

upstream raw materials:

thiophene-2-carbaldehyde

N'-cyclopropyl-4-fluoro-N-(5-methyl-2-phenyl-2H-pyrazol-3-yl)benzamidine

1-Phenyl-3-methyl-5-aminopyrazole

N-(cyclopropyl)-4-fluorobenzimidoyl chloride

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