4-[[5-ethoxy-2-(4-fluorophenyl)-2H-1,2,3-triazol-4-yl]methyl]-2-(trifluoromethyl)pyridine

Base Information

Chemical Name:4-[[5-ethoxy-2-(4-fluorophenyl)-2H-1,2,3-triazol-4-yl]methyl]-2-(trifluoromethyl)pyridine
CAS No.:1605969-45-6
Molecular Formula:C₁₇H₁₄F₄N₄O
Molecular Weight:366.318
Hs Code.:

Synonyms:4-[[5-ethoxy-2-(4-fluorophenyl)-2H-1,2,3-triazol-4-yl]methyl]-2-(trifluoromethyl)pyridine

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Chemical Property of 4-[[5-ethoxy-2-(4-fluorophenyl)-2H-1,2,3-triazol-4-yl]methyl]-2-(trifluoromethyl)pyridine

Chemical Property:

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Technology Process of 4-[[5-ethoxy-2-(4-fluorophenyl)-2H-1,2,3-triazol-4-yl]methyl]-2-(trifluoromethyl)pyridine

There total 5 articles about 4-[[5-ethoxy-2-(4-fluorophenyl)-2H-1,2,3-triazol-4-yl]methyl]-2-(trifluoromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1607442-42-1
[5-ethoxy-2-(4-fluorophenyl)-2H-1,2,3-triazol-4-yl][2-(trifluoromethyl)-4-pyridinyl]methanone

: 1605969-45-6
4-[[5-ethoxy-2-(4-fluorophenyl)-2H-1,2,3-triazol-4-yl]methyl]-2-(trifluoromethyl)pyridine

Guidance literature:: With iodine; hypophosphorous acid; acetic acid; In water; at 110 ℃; for 6h; Inert atmosphere;

Reference yield:

: 1607442-75-0
ethyl 5-ethoxy-2-(4-fluorophenyl)-2H-1,2,3-triazole-4-carboxylate

: 1605969-45-6
4-[[5-ethoxy-2-(4-fluorophenyl)-2H-1,2,3-triazol-4-yl]methyl]-2-(trifluoromethyl)pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: trimethylaluminum / toluene / 0.5 h / 0 °C / Inert atmosphere

1.2: 4 h / 23 °C / Inert atmosphere

2.1: TurboGrignard / tetrahydrofuran / 0.75 h / 0 - 23 °C

2.2: 22 h / 23 °C

3.1: iodine; hypophosphorous acid; acetic acid / water / 6 h / 110 °C / Inert atmosphere

With TurboGrignard; iodine; trimethylaluminum; hypophosphorous acid; acetic acid; In tetrahydrofuran; water; toluene;

Reference yield:

: 27317-59-5
Ethyl 3-ethoxy-3-iminopropionate

: 1605969-45-6
4-[[5-ethoxy-2-(4-fluorophenyl)-2H-1,2,3-triazol-4-yl]methyl]-2-(trifluoromethyl)pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.33 h / -15 - 5 °C

1.2: 0.5 h / 23 °C

1.3: 4 h / 90 °C

2.1: trimethylaluminum / toluene / 0.5 h / 0 °C / Inert atmosphere

2.2: 4 h / 23 °C / Inert atmosphere

3.1: TurboGrignard / tetrahydrofuran / 0.75 h / 0 - 23 °C

3.2: 22 h / 23 °C

4.1: iodine; hypophosphorous acid; acetic acid / water / 6 h / 110 °C / Inert atmosphere

With hydrogenchloride; TurboGrignard; iodine; trimethylaluminum; hypophosphorous acid; acetic acid; sodium nitrite; In tetrahydrofuran; water; toluene;