[5-ethoxy-2-(4-fluorophenyl)-2H-1,2,3-triazol-4-yl][2-(trifluoromethyl)-4-pyridinyl]methanone

Base Information

Chemical Name:[5-ethoxy-2-(4-fluorophenyl)-2H-1,2,3-triazol-4-yl][2-(trifluoromethyl)-4-pyridinyl]methanone
CAS No.:1607442-42-1
Molecular Formula:C₁₇H₁₂F₄N₄O₂
Molecular Weight:380.301
Hs Code.:

Synonyms:[5-ethoxy-2-(4-fluorophenyl)-2H-1,2,3-triazol-4-yl][2-(trifluoromethyl)-4-pyridinyl]methanone

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Chemical Property of [5-ethoxy-2-(4-fluorophenyl)-2H-1,2,3-triazol-4-yl][2-(trifluoromethyl)-4-pyridinyl]methanone

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Technology Process of [5-ethoxy-2-(4-fluorophenyl)-2H-1,2,3-triazol-4-yl][2-(trifluoromethyl)-4-pyridinyl]methanone

There total 4 articles about [5-ethoxy-2-(4-fluorophenyl)-2H-1,2,3-triazol-4-yl][2-(trifluoromethyl)-4-pyridinyl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1607442-76-1
5-ethoxy-2-(4-fluorophenyl)-N-methoxy-N-methyl-2H-1,2,3-triazole-4-carboxamide

: 590371-73-6
2-(trifluoromethyl)pyridine-4-iodide

: 1607442-42-1
[5-ethoxy-2-(4-fluorophenyl)-2H-1,2,3-triazol-4-yl][2-(trifluoromethyl)-4-pyridinyl]methanone

Guidance literature:: 2-(trifluoromethyl)pyridine-4-iodide; With TurboGrignard; In tetrahydrofuran; at 0 - 23 ℃; for 0.75h;

5-ethoxy-2-(4-fluorophenyl)-N-methoxy-N-methyl-2H-1,2,3-triazole-4-carboxamide; In tetrahydrofuran; at 23 ℃; for 22h;

Reference yield:

: 371-40-4
4-fluoroaniline

: 1607442-42-1
[5-ethoxy-2-(4-fluorophenyl)-2H-1,2,3-triazol-4-yl][2-(trifluoromethyl)-4-pyridinyl]methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.33 h / -15 - 5 °C

1.2: 0.5 h / 23 °C

1.3: 4 h / 90 °C

2.1: trimethylaluminum / toluene / 0.5 h / 0 °C / Inert atmosphere

2.2: 4 h / 23 °C / Inert atmosphere

3.1: TurboGrignard / tetrahydrofuran / 0.75 h / 0 - 23 °C

3.2: 22 h / 23 °C

With hydrogenchloride; TurboGrignard; trimethylaluminum; sodium nitrite; In tetrahydrofuran; water; toluene;

Reference yield:

: 1607442-75-0
ethyl 5-ethoxy-2-(4-fluorophenyl)-2H-1,2,3-triazole-4-carboxylate

: 1607442-42-1
[5-ethoxy-2-(4-fluorophenyl)-2H-1,2,3-triazol-4-yl][2-(trifluoromethyl)-4-pyridinyl]methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylaluminum / toluene / 0.5 h / 0 °C / Inert atmosphere

1.2: 4 h / 23 °C / Inert atmosphere

2.1: TurboGrignard / tetrahydrofuran / 0.75 h / 0 - 23 °C

2.2: 22 h / 23 °C

With TurboGrignard; trimethylaluminum; In tetrahydrofuran; toluene;